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| Clinical data | |
|---|---|
| Trade names | Flonase Nighttime Allergy Relief, Actidil, others |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | Oral: 4% |
| Protein binding | 90% |
| Metabolism | Hepatic (CYP2D6) |
| Elimination half-life | 4–6 hours |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.006.934 |
| Chemical and physical data | |
| Formula | C19H22N2 |
| Molar mass | 278.399 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 60 °C (140 °F) |
| Solubility in water | 500 mg/mL (20 °C) |
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  (what is this?) (verify) | |
Triprolidine is an over-the-counter antihistamine with anticholinergic properties. [1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. [2] As with many antihistamines, the most common side effect is drowsiness. [1]
Triprolidine was patented in 1948 and came into medical use in 1953, [3] and has mostly been replaced in popular medications by other antihistamines including diphenhydramine, promethazine, chlorpheniramine, as well as by second-generation antihistamines including loratadine and fexofenadine. Triprolidine remains an ingredient in the cold medicine Actifed in many territories.[ citation needed ]