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| Clinical data | |
|---|---|
| Trade names | Flonase Nighttime Allergy Relief, Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin) |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
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| Routes of administration | Oral |
| ATC code | |
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| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 4% oral |
| Protein binding | 90% |
| Metabolism | Hepatic (CYP2D6) |
| Elimination half-life | 4–6 hours |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
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| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.006.934 |
| Chemical and physical data | |
| Formula | C19H22N2 |
| Molar mass | 278.399 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 60 °C (140 °F) |
| Solubility in water | 500 mg/mL (20 °C) |
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  (what is this?) (verify) | |
Triprolidine is an over-the-counter antihistamine with anticholinergic properties. [1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. [2] As with many antihistamines, the most common side effect is drowsiness. [1]
Today, Triprolidine is used less frequently and has been replaced in popular medications by other antihistamines like Diphenhydramine, Promethazine, Chlorpheniramine, as well as second generation antihistamines like Loratadine and Fexofenadine. Triprolidine remains an ingredient in the cold medicine Actifed in many territories.
It was patented in 1948 and came into medical use in 1953. [3]