List of psychedelic drugs

This is a list of psychedelic drugs, also known as serotonergic psychedelics or classical hallucinogens. ^{[1] [2]} These drugs act specifically as serotonin 5-HT_2A receptor agonists. ^[3] They belong to three major structural families, including the tryptamines, phenethylamines, and lysergamides, although exceptions exist. ^{[4] [5] [6] [7]}

Tryptamines

Main article: Substituted tryptamine

No ring substitutions

• CYB004 (deuDMT)
• Diallyltryptamine (DALT)
• Dibutyltryptamine (DBT)
• Diethyltryptamine (DET; T-9)
• Diisopropyltryptamine (DiPT)
• Dimethyltryptamine (DMT)
• Dipropyltryptamine (DPT)
• Ethylisopropyltryptamine (EiPT)
• Ethylpropyltryptamine (EPT)
• Isopropylallyltryptamine (iPALT; ALiPT)
• Methylallyltryptamine (MALT)
• Methylcyclopropyltryptamine (McPT)
• Methylethyltryptamine (MET)
• Methylisopropyltryptamine (MiPT)
• Methylpropyltryptamine (MPT)
• N-Methyltryptamine (NMT)
• NBoc-DMT (NB-DMT)
• Propylallyltryptamine (PALT)
• Propylisopropyltryptamine (PiPT)
• SPL028 (D₂-DMT)
• Tryptamine (T) ^{[4] [8]}

4-Hydroxytryptamines

Main article: Substituted 4-hydroxytryptamine

• 4-HO-DALT (daltocin)
• 4-HO-DBT
• 4-HO-DET (ethocin; CZ-74)
• 4-HO-DiPT (iprocin)
• 4-HO-DPT (deprocin)
• 4-HO-EPT (eprocin)
• 4-HO-MALT (maltocin)
• 4-HO-McPT
• 4-HO-MET (metocin)
• 4-HO-MiPT (miprocin)
• 4-HO-MPT (meprocin)
• 4-HO-NALT
• 4-HO-NBnT
• 4-HO-NET
• 4-HO-NiPT
• 4-HO-NPT
• 4-HO-TMT
• 4-HO-5-MeO-DMT
• 4-Hydroxytryptamine (4-HO-T; 4-HT)
• 4-MeO-DMT
• CYB003 (deupsilocin)
• Psilocin (4-HO-DMT; CX-59)

4-Phosphoryloxytryptamines

• Aeruginascin (4-PO-TMT)
• Baeocystin (4-PO-NMT)
• Ethocybin (4-PO-DET; CEY-19)
• Norbaeocystin (4-PO-T)
• Psilocybin (4-PO-DMT; CY-39)

4-Acyloxytryptamines

• 4-AcO-DALT (daltacetin)
• 4-AcO-DET (ethacetin)
• 4-AcO-DiPT (ipracetin)
• 4-AcO-DMT (psilacetin)
• 4-AcO-DPT (depracetin)
• 4-AcO-EiPT (ethipracetin)
• 4-AcO-EPT
• 4-AcO-MALT
• 4-AcO-McPT
• 4-AcO-MET (metacetin)
• 4-AcO-MiPT (mipracetin)
• 4-AcO-MPT
• 4-GO-DMT (RE-109)
• 4-PrO-DiPT
• 4-PrO-DMT
• 4-PrO-MET
• Luvesilocin (4-GO-DiPT; RE-104, FT-104)

5-Hydroxytryptamines

Main article: Substituted 5-hydroxytryptamine

• 5-HO-MET
• Bufotenin (5-HO-DMT)
• Serotonin (5-HT; 5-HO-T)

5-Acyloxytryptamines

• O-Acetylbufotenine (5-AcO-DMT)
• O-Pivalylbufotenine (5-t-BuCO-DMT)

5-Methoxytryptamines

Main article: Substituted 5-methoxytryptamine

• 4-HO-5-MeO-DMT
• 5-MeO-2,N,N-TMT
• 5-MeO-DALT
• 5-MeO-DBT
• 5-MeO-DET
• 5-MeO-DiPT
• 5-MeO-DMT (mebufotenin)
• 5-MeO-DPT
• 5-MeO-EiPT
• 5-MeO-MALT
• 5-MeO-MET
• 5-MeO-MiPT
• 5-MeO-MsBT
• 5-MeO-NiPT
• 5-MeO-NMT
• 5-MeO-T-NBOMe
• 5-MeO-T-NB3OMe
• 5-Methoxytryptamine (5-MeO-T; 5-MT)
• ASR-3001 (5-MeO-iPALT)
• NB-5-MeO-DALT
• NB-5-MeO-MiPT

Other ring substitutions

• 2,N,N-TMT (2-methyl-DMT)
• 4,N,N-TMT (4-methyl-DMT)
• 5-Bromo-DMT
• 5-Chloro-DMT
• 5-Fluoro-DMT
• 5-PhO-T (OVT2)
• 5-N,N-TMT (5-methyl-DMT)
• 7,N,N-TMT (6-methyl-DMT)
• 5-MeO-2,N,N-TMT
• 6-Fluoro-DMT
• 6-Hydroxy-DET (6-HO-DET)
• Bretisilocin (GM-2505; 5-fluoro-MET)

α-Alkyltryptamines

Main article: Substituted α-alkyltryptamine

• 4-HO-AMT
• 4-Methyl-AMT
• 5-Fluoro-AMT
• 6-Fluoro-AMT
• AMT (Indopan)
• α-Methylserotonin (5-HO-αMT)
• α,N,N-TMT (α-Me-DMT; Alpha-N)
• N-Hydroxy-AMT

5-Methoxy-α-alkyltryptamines

• 5-MeO-AET
• 5-MeO-AMT (α,O-DMS; Alpha-O)
• α,N,O-TMS (5-MeO-α,N-DMT)
• α,N,N,O-TeMS (5-MeO-α,N,N-TMT)

Others

• N-DEAOP-Ts (e.g., N-DEAOP-NET, N-DEAOP-NMT, 5-MeO-N-DEAOP-NMT, 5-MeO-N-DEAOP-NET)

Structure undisclosed

• CT-4201
• EB-002 (EB-373)
• MSP-1014
• MYCO-004

Cyclized tryptamines

Main article: Cyclized tryptamine

• Ergolines/lysergamides (e.g., LSD)
• Ibogalogs (e.g., ibogainalog, tabernanthalog)
• O-Methylnordehydrobufotenine
• Partial ergolines (e.g., NDTDI, RU-28306, CT-5252)
• Piperidinylethylindoles (e.g., pip-T)
• Pyrrolidinylethylindoles (e.g., pyr-T, 5-MeO-pyr-T)
• Pyrrolidinylmethylindoles (e.g., MPMI, 4-HO-MPMI (lucigenol), 5-MeO-MPMI)
• Tetrahydropyridinylindoles (e.g., RU-28253 (5-MeO-THPI), NEtPhOH-THPI)

Tryptamine bioisosteres

Main article: Substituted tryptamine § Related compounds

• Benzofurans (e.g., 5-MeO-DiBF (1-oxa-5-MeO-DiPT), dimemebfe (5-MeO-BFE; 1-oxa-5-MeO-DMT), mebfap (5-MeO-3-APB; 1-oxa-5-MeO-AMT))
• Benzothiophenes (e.g., 3-APBT (1-thia-AMT))
• Indazolethylamines (e.g., AL-38022A, O-methyl-AL-34662)
• Indenylethylamines (e.g., C-DMT)
• Isotryptamines (e.g., 6-MeO-isoDMT, Ro60-0175)
• MYCO-005
• Quinolinylethylamines (e.g., mefloquine)

Phenethylamines

Main article: Substituted phenethylamine

Scalines

Main article: Scaline

• 2-Bromomescaline
• 3-TE
• 3-TM
• 4-Desoxymescaline (desoxy)
• 4-TE
• 4-TM
• Allylescaline
• Beta-D
• Cyclopropylmescaline
• Difluoroescaline
• Difluoromescaline
• N,N-Diformylmescaline
• Escaline
• Fluoroescaline
• Fluoroproscaline
• N-Formylmescaline
• Isobuscaline
• Isoproscaline
• Jimscaline
• Mescaline (3,4,5-TMPEA)
• Metadifluoromescaline (MDFM)
• Metaescaline
• Methallylescaline
• N-Methylmescaline (M-M)
• Proscaline
• Thioproscaline
• Tomscaline
• Trichocereine (N,N-dimethylmescaline; MM-M)
• Trifluoroescaline
• Trifluoromescaline

2C-x

Main article: 2C (psychedelics)

• 2C-B
• 2C-Bu
• 2C-C
• 2C-CN
• 2C-CP
• 2C-D
• 2C-E
• 2C-EF
• 2C-F
• 2C-H
• 2C-I
• 2C-iBu
• 2C-iP
• 2C-N
• 2C-P
• 2C-Se
• 2C-Se-TFM
• 2C-tBu
• 2C-TFE
• 2C-TFM
• 2C-YN
• 2C-V

2C-T-x

• 2C-T
• 2C-T-2
• 2C-T-3 (2C-T-20)
• 2C-T-4
• 2C-T-7
• 2C-T-8
• 2C-T-9
• 2C-T-13
• 2C-T-15
• 2C-T-16
• 2C-T-17
• 2C-T-19
• 2C-T-21
• 2C-T-21.5
• 2C-T-22
• 2C-T-25
• 2C-T-27
• 2C-T-28
• 2C-T-30
• CYB210010 (2C-T-TFM, 2C-T-36)

2C-O-x

• 2C-O (2,4,5-TMPEA; TMPEA-2)
• 2C-O-4
• 2C-O-22

Others

• 2C-B-AN
• 2C-DB
• 2C-G-x (e.g., 2C-G-3, 2C-G-5)
• β-Keto-2C-B (βk-2C-B)
• β-Keto-2C-I (βk-2C-I)
• β-Methyl-2C-B (BMB)
• BOx (e.g., BOB, BOD, BOH-2C-B)
• HOT-x (e.g., HOT-2, HOT-7, HOT-17)
• N-Ethyl-2C-B
• TWEETIOs (e.g., 2CB-2-EtO, 2CD-2-EtO, 2CD-5-EtO, 2CE-5-EtO, 2CE-5iPrO, 2CT2-5-EtO, ASR-2001 (2CB-5-PrO))

3C-x

Main article: 3C (psychedelics)

• 3C-AL
• 3C-BZ
• 3C-DFE
• 3C-E
• 3C-MAL
• 3C-P
• TMA (3C-M)

DOx

Main article: DOx (psychedelics)

• DOAM
• DOB
• DOBU
• DOC
• DOEF
• DOET
• DOH (2,5-DMA)
• DOI
• DOIB
• DOIP
• DOM
• DON
• DOPR
• DOTFM
• DOYN

Aleph-x (DOT-x)

• Aleph (DOT)
• Aleph-2
• Aleph-4
• Aleph-6
• Aleph-7

TMA-2 and derivatives (Mxx)

• MALM
• MEM
• MDFEM
• MFEM
• MIPM
• MMALM
• MPM
• MTFEM
• TMA-2

Others

• DODB
• DODC
• DOM-NBOMe
• DOTMA
• Ganeshas (G-x) (e.g., Ganesha (G, G-0), G-3, G-5)
• N-Hydroxy-DOM

4C-x

Main article: 4C (psychedelics)

• 4C-B
• 4C-C
• 4C-D (Ariadne)
• 4C-E
• 4C-I
• 4C-N
• 4C-P
• 4C-T-2

Ψ-PEA

Main article: Ψ-PEA (psychedelics)

• 2,4,6-TMPEA-NBOMe
• Ψ-2C-DFMO (ψ-2C-O-35)
• Ψ-2C-T-4
• Ψ-DODFMO
• Ψ-DOM
• TMA-6 (Ψ-TMA-2)

MDxx

Main article: Substituted methylenedioxyphenethylamine

• 5-Methyl-MDA
• 6-Methyl-MDA
• DMMDA
• DMMDA-2
• EIDA
• EMDA-2
• IDA
• Lophophine (MMDPEA)
• Lys-MDA
• MDA (tenamfetamine)
• MDHMA (FLEA; MDMOH)
• MDMA (midomafetamine; ecstasy)
• MDOH
• MMDA
• MMDA-2
• MMDA-3a
• MMDA-3b
• MMDMA
• N-t-BOC-MDMA
• (R)-MDMA

FLY

Main article: FLY (psychedelics)

• 2C-B-FLY
• 2C-B-BUTTERFLY
• 2C-B-DragonFLY
• 2CBFly-NBOMe
• Bromo-DragonFLY
• DOB-FLY
• DOH-FLY
• TFMFly

Hemi/semi-FLY drugs

• 2CB-5-hemiFLY
• DOH-5-hemiFLY (semi-fly; SF)
• DOB-5-hemiFLY (bromo-semi-fly; B-SF)

25x-NB (NBOMes)

Main article: 25-NB (psychedelics)

25x-NBOMe

• 25B-NBOMe
• 25C-NBOMe
• 25CN-NBOMe
• 25D-NBOMe
• 25E-NBOMe
• 25F-NBOMe
• 25G-NBOMe
• 25H-NBOMe
• 25I-NBOMe
• 25iP-NBOMe
• 25N-NBOMe
• 25O-NBOMe
• 25P-NBOMe
• 25T-NBOMe
• 25T2-NBOMe
• 25T4-NBOMe
• 25T7-NBOMe
• 25TFM-NBOMe

25x-NBOH

• 25B-NBOH
• 25C-NBOH
• 25CN-NBOH
• 25D-NBOH
• 25E-NBOH
• 25I-NBOH
• 25P-NBOH

Others

• 2,4,6-TMPEA-NBOMe
• 25B-NB (N-benzyl-2C-B)
• 2C-B-AN
• 2C2-NBOMe
• 2CBCB-NBOMe
• 2CBFly-NBOMe
• DOM-NBOMe
• NBOMe-escaline
• NBOMe-mescaline
• TGF-8027

Others

• 2-TOET
• 2-TOM
• 25B-NAcPip
• 4-HA
• 5-TOET
• 5-TOM
• Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22)
• Benzothiophenes (e.g., 5-APBT, 6-APBT)
• CT-5172
• DMAs (e.g., 2,4-DMA, 3,4-DMA)
• Fenfluramine
• MMA (3-MeO-4-MA)
• Norfenfluramine
• PEA-NDEPAs (e.g., 25D-NM-NDEAOP, DOB-NDEPA, DOI-NDEPA, DOM-NDEPA, DOTFM-NDEPA, M-NDEPA, TMA-2-NDEPA)
• PMA (4-MA)
• TMAs (e.g., TMA-3, TMA-4, TMA-5)
• TOMSO
• ZDCM-04

Structure undisclosed

• CYB005

Cyclized phenethylamines

Main article: Cyclized phenethylamine

• 1-Aminomethylindanes (e.g., 2CB-Ind, jimscaline)
• 2-Aminoindanes (e.g., DOM-AI)
• 3-Benzazepines (e.g., lorcaserin)
• 3-Phenylpiperidines (e.g., LPH-5, LPH-48)
• Benzocyclobutenes (e.g., 2CBCB-NBOMe, TCB-2, tomscaline)
• Benzoxepins (e.g., BBOX, IBOX, TFMBOX)
• DMBMPP (juncosamine)
• Ergolines/lysergamides (e.g., LSD)
• Glaucine
• Partial ergolines (e.g., NDTDI, DEIMDHPCA, DEMPDHPCA, DEMTMPDHPCA, DEMNDHPCA)
• Phenylcyclopropylamines (e.g., DMCPA, TMT)
• Phenyloxazolamines (aminorexes) (e.g., 2C-B-aminorex)
• Pyridopyrroloquinoxalines (e.g., IHCH-7113)
• Z3517967757
• ZC-B

Lysergamides

Main article: Substituted lysergamide

Amide-substituted lysergamides

• DAL
• DAM (DAM-57)
• DiPLA
• DPL
• EcPLA
• EiPLA
• EPLA (LEP; LEP-57)
• Ergine (LSA, LA-111)
• Ergometrine (ergonovine, ergobasine)
• ETFELA
• iPLA
• Isoergine (iso-LSA, iso-LA)
• LA-3Cl-SB (Cl-LSB)
• LAE (LAE-32)
• LAM
• LAMPA
• LAP
• LME (LME-54)
• LMP (LMP-55)
• LPD (LPD-824)
• LSB
• LSD (LSD-25, METH-LAD; lysergide)
• LSD-Pip
• LSDP (DPL)
• LSH (LAH)
• LSM (LSM-775)
• LSP
• LSZ (LA-SS-Az)
• Lysergic acid pyrrolinide (LPN)
• Methylergometrine (methylergonovine, methylergobasine)
• MiPLA

6-Alkyllysergamides

• BU-LAD
• CE-LAD (CHLORETH-LAD)
• CPM-LAD
• CYP-LAD (TRALA-22)
• ETH-LAD
• FLUORETH-LAD (FE-LAD)
• FP-LAD
• IP-LAD
• NBOMe-LAD
• PARGY-LAD
• PRO-LAD

1-Alkyllysergamides (prodrugs)

• Methysergide (1-methylmethylergonovine; UML-491)
• MLA-74 (1-methyl-LAE)
• MLD-41 (1-methyl-LSD)
• MPD-75 (1-methyl-LPD)
• OML-632 (1-hydroxymethyl-LSD)

1-Acyllysergamides (prodrugs)

• 1B-LSD
• 1BP-LSD
• 1Bz-LSD
• 1cP-AL-LAD
• 1cP-LSD
• 1cP-MiPLA
• 1D-AL-LAD
• 1D-LSD
• 1DD-LSD
• 1F-LSD
• 1Fe-LSD
• 1H-LSD
• 1P-AL-LAD
• 1P-ETH-LAD
• 1P-LSD
• 1P-MiPLA
• 1S-LSD
• 1SB-LSD (1BS-LSD)
• 1T-AL-LAD
• 1T-LSD
• 1V-LSD
• ALA-10 (1-acetyl-LAE; 1A-LAE)
• ALD-52 (1-acetyl-LSD; 1A-LSD)

Others

• 2,3-Dihydro-LSD
• 12-Hydroxy-LSD
• 12-Methoxy-LSD

Lysergamide bioisosteres

• JRT (isoindole-LSD)

Others

See also: List of miscellaneous 5-HT2A receptor agonists

• Arylpiperazines (e.g., 2C-B-PP, 2-NP, mCPP, MK-212, ORG-12962, pCPP, pFPP, quipazine, TFMPP)
• Dihydrobenzoxazines (e.g., efavirenz)
• Phenoxyethylamines (e.g., CT-4719, ORG-37684)
• Pyridopyrroloquinoxalines (e.g., IHCH-7113)
• Quinazolinylethylamines (e.g., RH-34)

Structure undisclosed

• BMB-202
• EGX-A
• EGX-B
• HBL20016
• Lucid-PSYCH (Lucid-201)
• MSP-4018
• MSP-4019
• MSP-4020

Natural sources

Main article: List of psychoactive plants, fungi, and animals

Tryptamines

• Acacia spp. (e.g., Acacia acuminata , Acacia confusa )
• Ayahuasca and vinho de Jurema (e.g., Psychotria viridis (chacruna), Dipolopterys cabrerana (chaliponga, chacruna), Mimosa tenuiflora (Mimosa hostilis; jurema))
• Brosimum (e.g., Brosimum acutifolium (takini))
• Hallucinogenic snuffs (e.g., Anadenanthera peregrina (yopo, jopo, cohoba, parica, ebene), Anadenanthera colubrina (vilca, cebil))
• Incilius alvarius (Bufo alvarius; Colorado River toad, Sonoran Desert toad; bufo)
• Psilocybin-containing mushrooms (magic mushrooms, shrooms) (e.g., Psilocybe cubensis , Psilocybe mexicana (teonanacatl))

Phenethylamines

• Pachycereus pringlei (saguesa, elephant cactus, cardon)
• Peyote (Lophophora williamsii; peyotl)
• Echinopsis cacti (e.g., San Pedro, Peruvian torch)

Lysergamides

• Achnatherum robustum (sleepy grass)
• Epichloë spp.
• Ergot (Claviceps) (e.g., Claviceps purpurea , Claviceps paspali )
• Morning glory (Convolvulaceae) seeds (e.g., Ipomoea tricolor (tlitliltzin, badoh negro; Ipomoea violacea), Ipomoea corymbosa (coaxihuitl, ololiúqui; Rivea Corymbosa, Turbina Corymbosa), Argyreia nervosa (Hawaiian baby woodrose; HBWR))
• Periglandula spp. (e.g., Periglandula ipomoeae , Periglandula clandestina )

See also

• List of drugs
• List of hallucinogens
• List of entheogens
• List of entactogens
• List of designer drugs
• List of investigational hallucinogens and entactogens
• Psychedelic plants
• PiHKAL and TiHKAL
• List of psychedelic chemists

References

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2. Nichols DE (April 2016). "Psychedelics". Pharmacol Rev. 68 (2): 264–355. doi:10.1124/pr.115.011478. PMC   4813425 . PMID   26841800.
3. Gumpper RH, Nichols DE (October 2024). "Chemistry/structural biology of psychedelic drugs and their receptor(s)". Br J Pharmacol. doi:10.1111/bph.17361. PMID   39354889.
4. Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN   0-9630096-9-9. OCLC   38503252.
5. Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN   0-9630096-0-5. OCLC   25627628.
6. Trachsel, D.; Lehmann, D.; Enzensperger, C. (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN   978-3-03788-700-4. OCLC   858805226. Archived from the original on 21 August 2025.
7. Nichols DE (2018). "Chemistry and Structure-Activity Relationships of Psychedelics". Curr Top Behav Neurosci. 36: 1–43. doi:10.1007/7854_2017_475. PMID   28401524.
8. Martin WR, Sloan JW (1970). "Effects of infused tryptamine in man". Psychopharmacologia. 18 (3): 231–237. doi:10.1007/BF00412669. PMID   4922520.