E-55888

Last updated
E-55888
E-55888 structure.png
Identifiers
  • N,N-dimethyl-3-(1,3,5-trimethyl-1H-pyrazol-4-yl)phenethylamine
ChemSpider
Chemical and physical data
Formula C16H23N3
Molar mass 257.381 g·mol−1
3D model (JSmol)
  • Cn1nc(C)c(c1C)-c(c2)cccc2CCN(C)C
  • InChI=1S/C16H23N3/c1-12-16(13(2)19(5)17-12)15-8-6-7-14(11-15)9-10-18(3)4/h6-8,11H,9-10H2,1-5H3
  • Key:MFUWRMRKXKCSPL-UHFFFAOYSA-N
   (verify)

E-55888 is a drug developed by Esteve, which acts as a potent and selective full agonist at the 5HT7 serotonin receptor, and is used for investigating the role of 5-HT7 receptors in the perception of pain. When administered by itself, E-55888 is anti-hyperalgesic but not analgesic, but when administered alongside morphine, E-55888 was found to significantly increase the analgesic effects. [1] [2]

See also

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References

  1. Brenchat A, Romero L, García M, Pujol M, Burgueño J, Torrens A, Hamon M, Baeyens JM, Buschmann H, Zamanillo D, Vela JM (February 2009). "5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice". Pain. 141 (3): 239–47. doi:10.1016/j.pain.2008.11.009. PMID   19118950. S2CID   27144262.
  2. Brenchat A, Ejarque M, Zamanillo D, Vela JM, Romero L (August 2011). "Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT(7) Receptors". Journal of Pharmacological Sciences. 116 (4): 388–91. doi: 10.1254/jphs.11039sc . PMID   21778664.