6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide

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6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
CEPC.svg
Identifiers
  • 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C16H16ClN3O2
Molar mass 317.77 g·mol−1
3D model (JSmol)
  • c3cccnc3NC(=O)N(c1cc2Cl)CCc1cc2OCC
  • InChI=1S/C16H16ClN3O2/c1-2-22-14-9-11-6-8-20(13(11)10-12(14)17)16(21)19-15-5-3-4-7-18-15/h3-5,7,9-10H,2,6,8H2,1H3,(H,18,19,21)
  • Key:OCFLVVOXCVJFTI-UHFFFAOYSA-N

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide (CEPC) is a drug which acts as a potent and selective antagonist for the serotonin 5-HT2C receptor. In animal studies it was found to potentiate the conditioned place preference induced by low-dose amphetamine, demonstrating that 5-HT2C-mediated disinhibition of dopamine release can cause interactions with dopaminergic drugs. [1]

See also

References

  1. ↑ McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011). "A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference". Neuroscience Letters. 505 (1): 10–3. doi:10.1016/j.neulet.2011.07.036. PMC   3213641 . PMID   21827831.
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