Last updated
Rizatriptan Structural Formula V.1.svg
Rizatriptan 3D ball-and-stick.png
Clinical data
Trade names Maxalt, others
AHFS/Drugs.com Monograph
MedlinePlus a601109
License data
  • AU:B1
Routes of
By mouth
Drug class Triptan
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)/ S3
  • CA: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 45%
Protein binding 14%
Metabolism By monoamine oxidase
Elimination half-life 2–3 hours
Excretion 82% urine; 12% faeces
  • N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard 100.243.719 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C15H19N5
Molar mass 269.352 g·mol−1
3D model (JSmol)
  • n1cncn1Cc2cc3c(cc2)[nH]cc3CCN(C)C
  • InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3 Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Rizatriptan, sold under the brand name Maxalt among others, is a medication used for the treatment of migraine headaches. [1] It is taken by mouth. [1]


Common side effects include chest pain, dizziness, dry mouth, and tingling. [1] Other side effects may include myocardial infarction, stroke, high blood pressure, serotonin syndrome, and anaphylaxis. [1] Excessive use may result in medication overuse headaches. [1] Use is not recommended during pregnancy and breastfeeding is not recommended within 24 hours after taking a dose. [2] Rizatriptan is in the triptan class and is believed to work by activating the 5-HT1 receptor. [1]

Rizatriptan was patented in 1991 and came into medical use in 1998. [3] It is available as a generic medication. [2] In 2020, it was the 134th most commonly prescribed medication in the United States, with more than 4 million prescriptions. [4] [5]

Medical uses

Rizatriptan is used to treat acute migraine attacks with or without aura. It does not prevent future migraine attacks. [6] A 2010 review found rizatriptan to be more efficacious and tolerable than sumatriptan. [7]


Rizatriptan and other triptans can cause vasoconstriction, they are contraindicated in people with cardiovascular conditions. [8]

Adverse effects

Frequent adverse effects (incidence less than 10%) are dizziness, drowsiness, asthenia/fatigue, and nausea. Clinical adverse experiences were typically mild and short-lasting (2–3 hours). [8]


Mechanism of action

Rizatriptan acts as an agonist at serotonin 5-HT1B and 5-HT1D receptors. [10] Like the other triptans sumatriptan and zolmitriptan, rizatriptan induces vasoconstriction—possibly by inhibiting the release of calcitonin gene-related peptide from sensory neurons in the trigeminal nerve. [10]


Brand names include Bizaliv, Rizalt, Rizact (India) and Maxalt.

Related Research Articles

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Sumatriptan, sold commonly under brand names Imitrex and Treximet among others, is a medication used to treat migraine headaches and cluster headaches. It is taken orally, intranasally, or by subcutaneous injection. Therapeutic effects generally occur within three hours.

<span class="mw-page-title-main">Ergotamine</span> Chemical compound in the ergot family of alkaloids

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<span class="mw-page-title-main">Prochlorperazine</span> Medication for nausea, psychosis, and anxiety

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<span class="mw-page-title-main">Dihydroergotamine</span> An ergot alkaloid used to treat migraines

Dihydroergotamine (DHE), sold under the brand names D.H.E. 45 and Migranal among others, is an ergot alkaloid used to treat migraines. It is a derivative of ergotamine. It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan. Nausea is a common side effect.

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  1. 1 2 3 4 5 6 "Rizatriptan Benzoate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.
  2. 1 2 British National Formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 473. ISBN   9780857113382.
  3. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN   9783527607495.
  4. "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  5. "Rizatriptan - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
  6. "Rizatriptan". MedlinePlus. U.S. National Library of Medicine.
  7. Göbel H (2010). "Efficacy and tolerability of rizatriptan 10 mg compared with sumatriptan 100 mg: an evidence-based analysis". Expert Rev Neurother. 10 (4): 499–506. doi:10.1586/ern.10.24. PMID   20367203. S2CID   43395810.
  8. 1 2 Hargreaves RJ, Lines CR, Rapoport AM, Ho TW, Sheftell FD (2009). "Ten years of rizatriptan: from development to clinical science and future directions". Headache. 49: S3–S20. doi:10.1111/j.1526-4610.2008.01335.x. PMID   19161563. S2CID   23587019.
  9. Millson DS, Tepper SJ, Rapoport AM (March 2000). "Migraine pharmacotherapy with oral triptans: a rational approach to clinical management". Expert Opinion on Pharmacotherapy. 1 (3): 391–404. doi:10.1517/14656566.1.3.391. PMID   11249525. S2CID   36053513.
  10. 1 2 Wellington K, Plosker GL (2002). "Rizatriptan: an update of its use in the management of migraine". Drugs. 62 (10): 1539–74. doi:10.2165/00003495-200262100-00007. PMID   12093318.