Zavegepant

Last updated

Zavegepant
Zavegepant.svg
Clinical data
Trade names Zavzpret
Other namesBHV-3500
License data
Routes of
administration
Nasal
Drug class Calcitonin gene-related peptide receptor antagonist
ATC code
Legal status
Legal status
Identifiers
  • N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C36H46N8O3
Molar mass 638.817 g·mol−1
3D model (JSmol)
  • CC1=CC(=CC2=C1NN=C2)CC(C(=O)N3CCN(CC3)C4CCN(CC4)C)NC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O
  • InChI=1S/C36H46N8O3/c1-24-19-25(20-28-23-37-40-33(24)28)21-32(35(46)43-17-15-42(16-18-43)29-9-11-41(2)12-10-29)39-36(47)44-13-7-26(8-14-44)30-22-27-5-3-4-6-31(27)38-34(30)45/h3-6,19-20,22-23,26,29,32H,7-18,21H2,1-2H3,(H,37,40)(H,38,45)(H,39,47)/t32-/m1/s1
  • Key:JJVAPHYEOZSKJZ-JGCGQSQUSA-N
  • Key:VQDUWCSSPSOSNA-RYWNGCACSA-N

Zavegepant, sold under the brand name Zavzpret, is a medication used for the treatment of migraine. [1] Zavegepant is a calcitonin gene-related peptide receptor antagonist. [1] It is sprayed into the nose. [1] It is sold by Pfizer. [1]

Contents

The most common adverse reactions include taste disorders, nausea, nasal discomfort, and vomiting. [1]

Zavegepant was approved for medical use in the United States in March 2023. [1] [2] [3] [4]

Medical uses

Zavegepant is indicated for the acute treatment of migraine with or without aura in adults. [1] [5] [6]

References

  1. 1 2 3 4 5 6 7 8 "Zavzpret- zavegepant spray". DailyMed. 9 March 2023. Retrieved 25 August 2023.
  2. "Drug Approval Package: Zavzpret". U.S. Food and Drug Administration (FDA). 3 April 2023. Archived from the original on 25 August 2023. Retrieved 25 August 2023.
  3. "Pfizer's Zavzpret (Zavegepant) Migraine Nasal Spray Receives FDA Approval" (Press release). 10 March 2023.
  4. Dhillon S (June 2023). "Zavegepant: First Approval". Drugs. 83 (9): 825–831. doi:10.1007/s40265-023-01885-6. PMC   10209931 . PMID   37227596.
  5. Khan ZZ, Ahmed U, Shahzad F, Ali M, Tousif K, Ahmed U, et al. (July 2023). "Safety and Efficacy of Zavegepant in Treating Migraine: A Systematic Review". Cureus. 15 (7): e41991. doi: 10.7759/cureus.41991 . PMC   10428082 . PMID   37593294.
  6. Martirosov AL, Giuliano C, Shupp M, Channey S, Kale-Pradhan PB (October 2023). "Zavegepant Intranasal Spray for Migraines". The Annals of Pharmacotherapy. 58 (8): 827–833. doi:10.1177/10600280231209439. PMID   37897226. S2CID   264543368.

Further reading