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By mouth
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Legal status
  • In general: ℞ (Prescription only)
  • 5,6-Dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
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Chemical and physical data
Formula C23H29N3O2
Molar mass 379.504 g·mol−1
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  • InChI=1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3 X mark.svgN
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Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia. [1] It was also evaluated for the treatment of anxiety at a dosage of 20 mg per day. [2] Chemically, it is an indole and phenylpiperazine derivative. [3] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy. [4] Its structure is similar to solypertine and milipertine.

See also

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Serotonin reuptake inhibitor Class of drug

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5-Chloro-αMT Chemical compound

5-Chloro-α-methyltryptamine (5-Chloro-αMT), also known as PAL-542, is a tryptamine derivative related to α-methyltryptamine (αMT) and one of only a few known specific serotonin-dopamine releasing agents (SDRAs). It has been investigated in animals as a potential treatment for cocaine dependence. The EC50 values of 5-chloro-αMT in evoking the in vitro release of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in rat synaptosomes were reported as 16 nM, 54 nM, and 3434 nM, with an NE/DA ratio of 63.6 and a DA/5-HT ratio of 3.38, indicating that it is a highly specific and well-balanced SDRA. However, 5-chloro-αMT has also been found to act as a potent full agonist of the 5-HT2A receptor, with an EC50 value of 6.27 nM and an efficacy of 105%, and almost assuredly acts as a potent agonist of other serotonin receptors as well.


  1. Hall, Chapman and; Rhodes, P. H (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN   0-412-54090-8.
  2. Somohano MD, Broissin MC, Sobrino z A. [Clinical evaluation of oxypertine in anxiety conditions]. Neurol Neurocir Psiquiatr. 1976;17(3):171-80.
  3. Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]". Acta Neurol Psychiatr Belg (in French). 68 (2): 116–27. PMID   4972600.
  4. Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift für Zellforschung und mikroskopische Anatomie. 101 (3): 448–62. doi:10.1007/BF00335580. PMID   5362847. S2CID   32583722.