Diphenylbutylpiperidine

Base chemical structure of the diphenylbutylpiperidine antipsychotics.

Diphenylbutylpiperidines are a class of typical antipsychotic drugs which were all synthesized, developed, and marketed by Janssen Pharmaceutica. ^{[1] [2]}

They include:

• Clopimozide (R-29,764)
• Fluspirilene (Redeptin)
• Penfluridol (Semap, Micefal, Longoperidol)
• Pimozide (Orap)

A closely related antipsychotic, amperozide, has an additional nitrogen atom in the heterocyclic ring and is classified as a diphenylbutylpiperazine. ^[3]

Other diphenylbutylpiperazines include lidoflazine, PR-000608, FG5865, FG-5893, mioflazine & difluanazine. ^{[4] [5]} .

References

1. Galizzi JP, Fosset M, Romey G, Laduron P, Lazdunski M (October 1986). "Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors". Proceedings of the National Academy of Sciences of the United States of America. 83 (19): 7513–7. Bibcode:1986PNAS...83.7513G. doi: 10.1073/pnas.83.19.7513 . PMC   386749 . PMID   2429309.
2. Qar J, Galizzi JP, Fosset M, Lazdunski M (September 1987). "Receptors for diphenylbutylpiperidine neuroleptics in brain, cardiac, and smooth muscle membranes. Relationship with receptors for 1,4-dihydropyridines and phenylalkylamines and with Ca2+ channel blockade". European Journal of Pharmacology. 141 (2): 261–8. doi:10.1016/0014-2999(87)90271-8. PMID   2445589.
3. Figueras, Albert; Capellà, Dolors (1993). Antipsychotic drugs. Side Effects of Drugs Annual. Vol. 17. pp. 49–71. doi:10.1016/S0378-6080(05)80189-8. ISBN   978-0-444-82005-1.
4. "Difluanazine". PubChem. U.S. National Library of Medicine.
5. US 3267104,Hermans HK, Karl-Adolf SW,"1,4-Disubstituted piperazines and diazepines",issued 16 August 1966, assigned to Janssen Pharmaceutica NV