Less than 30% BPRS reduction Follow-up: mean 5 weeks
The average overall mental state score in the perazine group was lower than for those given other antipsychotic drugs but the difference between the groups was not clear. These findings are based on data of low quality.
Needing antiparkinson medication Follow-up: average 5 weeks
Perazine might increase the risk of experiencing this outcome but at present it is not possible to be confident about the difference between perazine and other antipsychotic drugs. Data supporting this finding are very limited.
Leaving the study early - due to adverse events Follow-up: average 4 weeks
There was not a clear difference between perazine and the other antipsychotic drugs for this general outcome reflecting overall adverse event 'load'. These findings are based on data of low quality.
Phenothiazine-10-propionitrile [1698-80-2] (1) is treated with a mixture of acid and alcohol giving Methyl phenothiazinepropionate, CID:368244 (2). Heating with 1-methylpiperazine (3) gives the amide [91508-47-3] (4). Reduction of this last by means of diborane yields Perazine (5).
Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia. It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines. It is of the phenothiazine chemical class.
The Zeisel determination or Zeisel test is a chemical test for the presence of esters or ethers in a chemical substance. It is named after the Czech chemist Simon Zeisel (1854–1933). In a qualitative test a sample is first reacted with a mixture of acetic acid and hydrogen iodide in a test tube. The ensuing reaction results in the cleavage of the ether or the ester into an alkyl iodide and respectively an alcohol or a carboxylic acid.
Tantalum hafnium carbide is a refractory chemical compound with a general formula TaxHfy-xCy, which can be considered as a solid solution of tantalum carbide and hafnium carbide. It was originally thought to have the highest melting of any known substance but new research has proven that hafnium carbonitride has a higher melting point.
The Rosenmund–von Braun synthesis is an organic reaction in which an aryl halide reacts with cuprous cyanide to yield an aryl nitrile.
Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.
Trimethylsulfonium is an organic cation with the chemical formula (CH3)3S+.
Ilmenium was the proposed name for a new element found by the chemist R. Hermann in 1847. During the analysis of the mineral samarskite, he concluded that it does contain an element similar to niobium and tantalum. The similar reactivity of niobium and tantalum complicated preparation of pure samples of the metals and therefore several new elements were proposed, which were later found to be mixtures of niobium and tantalum.
Conhydrine is a poisonous alkaloid found in poison hemlock in small quantities.
Levopropylhexedrine (Eventin) is an adrenergic alkylamine used as an anorectic in Germany and patented by Smith Kline & French in 1947. It has also been used in the anticonvulsant preparation barbexaclone in combination with phenobarbital to offset sedation. Levopropylhexedrine is the levorotatory S-enantiomer of propylhexedrine. The dextrorotatory counterpart is known as dextropropylhexedrine.
Quercitannic acid is one of the two forms of tannic acid found in oak bark and leaves. The other form is called gallotannic acid and is found in oak galls.
In inorganic chemistry, a Nowotny chimney ladder phase is a particular intermetallic crystal structure found with certain binary compounds. NLC phases are generally tetragonal and are composed of two separate sublattices. The first is a tetragonal array of transition metal atoms, generally from group 4 through group 9 of the periodic table. Contained within this array of transition metal atoms is a second network of main group atoms, typically from group 13 or group 14. The transition metal atoms form a chimney with helical zigzag chain. The main-group elements form a ladder spiraling inside the transition metal helix.
The Bohn–Schmidt reaction, a named reaction in chemistry, introduces a hydroxy group at an anthraquinone system. The anthraquinone must already have at least one hydroxy group. The reaction was first described in 1889 by René Bohn (1862–1922) and in 1891 by Robert Emanuel Schmidt (1864–1938), two German industrial chemists.
Hermann Fritz Gustav Goos was a German physicist and astronomer.
Otfrid Mittmann was a German mathematician. Starting in 1927, he studied mathematics and natural sciences in Göttingen and Leipzig, and got his Ph.D. in Apr 1935. He joined the Nazi movement in Oct 1929. and published on statistical aspects of Nazi eugenics. After the war, he published in Göttingen and Bonn.
Wilhelm Gross was an Austrian mathematician, known for the Gross star theorem.
Ramalic acid is an organic compound with the molecular formula C18H18O7. Ramalic acid occurs as a secondary metabolite in some lichens like Ramalina pollinaria wherfrom ramalic acid has its name. Ramalic acid can be used as a dye.
A selenate selenite is a chemical compound or salt that contains selenite and selenate anions (SeO32- and SeO42-). These are mixed anion compounds. Some have third anions.
Phosphide carbides or carbide phosphides are compounds containing anions composed of carbide (C4−) and phosphide (P3−). They can be considered as mixed anion compounds. Related compounds include the phosphide silicides, germanide phosphides, arsenide carbides, nitride carbides and silicide carbides.
Hexafluorotitanic acid (systematically named oxonium hexafluoridotitanate(2-)) is an inorganic compound with the chemical formula (H3O)(H5O2)[TiF6]. According to X-ray crystallography, the salt consists of [TiF6]2- octahedral and two kinds of oxonium cations, (H3O)+ and (H5O2)+.
Thioquinanthrene, also known as thiochinathren, is an aromatic organic chemical compound. It has the chemical formula C18H10N2S2 and reacts with alcoholates or alkoxides. One of the key uses is to act as a catalyst poison in the Rosenmund reduction. It has the IUPAC name of 2,13-dithia-10,21-diazapentacyclo[12.8.0.03,12.04,9.015,20]docosa-1(14),3(12),4,6,8,10,15,17,19,21-decaene.
↑ Hromatka, O.; Sauter, F.; Schlager, L. H. (1957). "Untersuchungen über Phenthiazinderivate III: Über die Synthese von 10-(Piperazinoalkyl)-phenthiazinen". Monatshefte für Chemie. 88 (2): 193–201. doi:10.1007/BF00901625.
↑ Hromatka, O.; Stehlik, G.; Sauter, F. (1960). "Untersuchungen über Phenthiazinderivate, 12. Mitt.: Reaktionen zur Géwinnung von 10-(?-Methylpiperazinylpropyl)-phenthiazin". Monatshefte für Chemie 91 (1): 107–116. doi:10.1007/BF00903173.
This page is based on this Wikipedia article Text is available under the CC BY-SA 4.0 license; additional terms may apply. Images, videos and audio are available under their respective licenses.
(what is this?) (verify) 
