Less than 30% BPRS reduction Follow-up: mean 5 weeks
The average overall mental state score in the perazine group was lower than for those given other antipsychotic drugs but the difference between the groups was not clear. These findings are based on data of low quality.
Needing antiparkinson medication Follow-up: average 5 weeks
Perazine might increase the risk of experiencing this outcome but at present it is not possible to be confident about the difference between perazine and other antipsychotic drugs. Data supporting this finding are very limited.
Leaving the study early - due to adverse events Follow-up: average 4 weeks
There was not a clear difference between perazine and the other antipsychotic drugs for this general outcome reflecting overall adverse event 'load'. These findings are based on data of low quality.
Phenothiazine-10-propionitrile [1698-80-2] (1) is treated with a mixture of acid and alcohol giving Methyl phenothiazinepropionate, CID:368244 (2). Heating with 1-methylpiperazine (3) gives the amide [91508-47-3] (4). Reduction of this last by means of diborane yields Perazine (5).
Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history.
Ethyl nitrate is the ethyl ester of nitric acid and has the chemical formula C2H5NO3. It is a colourless, volatile, explosive, and extremely flammable liquid. It is used in organic synthesis with use as a nitrating agent and as an intermediate in the preparation of some drugs, dyes, and perfumes. Like nitroglycerin, it's a vasodialator.
The Zeisel determination or Zeisel test is a chemical test for the presence of esters or ethers in a chemical substance.
The Hunsdiecker reaction is a name reaction in organic chemistry whereby silver salts of carboxylic acids react with a halogen to produce an organic halide. It is an example of both a decarboxylation and a halogenation reaction as the product has one fewer carbon atoms than the starting material and a halogen atom is introduced its place. A catalytic approach has been developed.
Silicon disulfide is the inorganic compound with the formula SiS2. Like silicon dioxide, this material is polymeric, but it adopts a 1-dimensional structure quite different from the usual forms of SiO2.
Paul Friedländer was a German chemist best known for his research on derivates of indigo and isolation of Tyrian purple from Murex brandaris.
Boron sulfide is the chemical compound with the formula B2S3. It is a white, moisture-sensitive solid. It has a polymeric structure. The material has been of interest as a component of "high-tech" glasses and as a reagent for preparing organosulfur compounds.
Tantalum hafnium carbide is a refractory chemical compound with a general formula TaxHfyCx+y, which can be considered as a solid solution of tantalum carbide and hafnium carbide. It was originally thought to have the highest melting of any known substance but new research has proven that hafnium carbonitride has a higher melting point.
In chemistry, a chemical transport reaction describes a process for purification and crystallization of non-volatile solids. The process is also responsible for certain aspects of mineral growth from the effluent of volcanoes. The technique is distinct from chemical vapor deposition, which usually entails decomposition of molecular precursors (e.g. SiH4 → Si + 2 H2) and which gives conformal coatings. The technique, which was popularized by Harald Schäfer, entails the reversible conversion of nonvolatile elements and chemical compounds into volatile derivatives. The volatile derivative migrates throughout a sealed reactor, typically a sealed and evacuated glass tube heated in a tube furnace. Because the tube is under a temperature gradient, the volatile derivative reverts to the parent solid and the transport agent is released at the end opposite to which it originated (see next section). The transport agent is thus catalytic. The technique requires that the two ends of the tube (which contains the sample to be crystallized) be maintained at different temperatures. So-called two-zone tube furnaces are employed for this purpose. The method derives from the Van Arkel de Boer process which was used for the purification of titanium and vanadium and uses iodine as the transport agent.
The Rosenmund–von Braun synthesis is an organic reaction in which an aryl halide reacts with cuprous cyanide to yield an aryl nitrile.
Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.
Trimethylsulfonium is an organic cation with the chemical formula (CH3)3S+.
Conhydrine is a poisonous alkaloid found in poison hemlock in small quantities.
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In inorganic chemistry, a Nowotny chimney ladder phase is a particular intermetallic crystal structure found with certain binary compounds. NLC phases are generally tetragonal and are composed of two separate sublattices. The first is a tetragonal array of transition metal atoms, generally from group 4 through group 9 of the periodic table. Contained within this array of transition metal atoms is a second network of main group atoms, typically from group 13 or group 14. The transition metal atoms form a chimney with helical zigzag chain. The main-group elements form a ladder spiraling inside the transition metal helix.
The Bohn–Schmidt reaction, a named reaction in chemistry, introduces a hydroxy group at an anthraquinone system. The anthraquinone must already have at least one hydroxy group. The reaction was first described in 1889 by René Bohn (1862–1922) and in 1891 by Robert Emanuel Schmidt (1864–1938), two German industrial chemists.
Difluorophosphate or difluorodioxophosphate or phosphorodifluoridate is an anion with formula PO2F−2. It has a single negative charge and resembles perchlorate and monofluorosulfonate in shape and compounds. These ions are isoelectronic, along with tetrafluoroaluminate, phosphate, orthosilicate, and sulfate. It forms a series of compounds. The ion is toxic to mammals as it causes blockage to iodine uptake in the thyroid. However it is degraded in the body over several hours.
N,N,N′,N′-Tetramethylformamidinium chloride is the simplest representative of quaternary formamidinium cations of the general formula [R2N−CH=NR2]+ with a chloride as a counterion in which all hydrogen atoms of the protonated formamidine [HC(=NH2)NH2]+ are replaced by methyl groups.
A selenate selenite is a chemical compound or salt that contains selenite and selenate anions (SeO32- and SeO42-). These are mixed anion compounds. Some have third anions.
Phosphide carbides or carbide phosphides are compounds containing anions composed of carbide (C4−) and phosphide (P3−). They can be considered as mixed anion compounds. Related compounds include phosphide silicides, germanide phosphides, arsenide carbides, nitride carbides and silicide carbides.
↑ Hromatka, O.; Sauter, F.; Schlager, L. H. (1957). "Untersuchungen über Phenthiazinderivate III: Über die Synthese von 10-(Piperazinoalkyl)-phenthiazinen". Monatshefte für Chemie. 88 (2): 193–201. doi:10.1007/BF00901625.
↑ Hromatka, O.; Stehlik, G.; Sauter, F. (1960). "Untersuchungen über Phenthiazinderivate, 12. Mitt.: Reaktionen zur Géwinnung von 10-(?-Methylpiperazinylpropyl)-phenthiazin". Monatshefte für Chemie 91 (1): 107–116. doi:10.1007/BF00903173.
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