Tolonidine

Tolonidine

Names
Preferred IUPAC name N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
Identifiers
CAS Number	4201-22-3  Y
3D model (JSmol)	Interactive image
ChemSpider	65112  N
KEGG	D07168  Y
PubChem CID	72138
UNII	I4O795Q03O  Y
CompTox Dashboard (EPA)	DTXSID80194815
InChI InChI=1S/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14) N Key: KWBTZIFLQYYPTH-UHFFFAOYSA-N N InChI=1/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14) Key: KWBTZIFLQYYPTH-UHFFFAOYAF
SMILES Clc1cc(C)ccc1NC2=NCCN2
Properties
Chemical formula	C10H12ClN3
Molar mass	209.67538
Pharmacology
ATC code	C02AC04 ( WHO )
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

Tolonidine is an antihypertensive. ^{[1] [2] [3]} It is an imidazoline receptor agonist, like moxonidine and rilmenidine.

See also

• Clonidine

References

1. Cosnier, D.; Duchene-Marullaz, P.; Grimal, J.; Rispat, G.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate". Arzneimittel-Forschung. 25 (10): 1557–61. PMID   1243037.
2. Cosnier, D.; Labrid, C.; Rispat, G.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis". Arzneimittel-Forschung. 25 (11): 1802–6. PMID   1243090.
3. Cosnier, D.; Hache, J.; Labrid, C.; Streichenberger, G. (1975). "Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity". Arzneimittel-Forschung. 25 (12): 1926–33. PMID   3186.