Primidolol

Primidolol

Names
IUPAC name 1-[2-[[2-Hydroxy-3-(2-methylphenoxy)propyl]amino]ethyl]-5-methylpyrimidine-2,4-dione
Identifiers
CAS Number	67227-55-8  Y
3D model (JSmol)	Interactive image
ChemSpider	61835
KEGG	C11774
PubChem CID	68563
UNII	56QH73D78K  Y
CompTox Dashboard (EPA)	DTXSID0043840
InChI InChI=1S/C17H23N3O4/c1-12-5-3-4-6-15(12)24-11-14(21)9-18-7-8-20-10-13(2)16(22)19-17(20)23/h3-6,10,14,18,21H,7-9,11H2,1-2H3,(H,19,22,23) Key: RETPFDTUCPKFEC-UHFFFAOYSA-N
SMILES CC1=CC=CC=C1OCC(CNCCN2C=C(C(=O)NC2=O)C)O
Properties
Chemical formula	C17H23N3O4
Molar mass	333.388 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Primidolol is a beta adrenergic receptor antagonist. ^{[1] [2] [3]}

References

1. Saltvedt, E; Fauchald, P (1980). "Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension". Current Medical Research and Opinion. 6 (8): 528–33. doi:10.1185/03007998009109482. PMID   6104564.
2. Augstein, J.; Cox, D. A.; Ham, A. L.; Leeming, P. R.; Snarey, M. (1973). "Beta-adrenoceptor blocking agents. 1. Cardioselective 1-aryloxy-3-(aryloxyalkylamino)propan-2-ols". Journal of Medicinal Chemistry. 16 (11): 1245–1251. doi:10.1021/jm00269a007. PMID   4147835.
3. DE 2238504,Augstein, Joachim; Cox, David Alexander& Ham, Allan Leslie,"Propanolaminderivate [Propanolamine derivates]",published 1973-02-22, assigned to Pfizer Corp.