Brefonalol

Last updated
Brefonalol
Brefanolol.svg
Names
IUPAC name
6-[1-Hydroxy-2-[(2-methyl-4-phenylbutan-2-yl)amino]ethyl]-3,4-dihydro-1H-quinolin-2-one
Other names
Brefanolol
Identifiers
  • 104051-20-9 Yes check.svgY
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
UNII
  • InChI=1S/C22H28N2O2/c1-22(2,13-12-16-6-4-3-5-7-16)23-15-20(25)18-8-10-19-17(14-18)9-11-21(26)24-19/h3-8,10,14,20,23,25H,9,11-13,15H2,1-2H3,(H,24,26)
    Key: YYUZPBGIBVJYSI-UHFFFAOYSA-N
  • InChI=1/C22H28N2O2/c1-22(2,13-12-16-6-4-3-5-7-16)23-15-20(25)18-8-10-19-17(14-18)9-11-21(26)24-19/h3-8,10,14,20,23,25H,9,11-13,15H2,1-2H3,(H,24,26)
    Key: YYUZPBGIBVJYSI-UHFFFAOYAN
  • CC(C)(CCC1=CC=CC=C1)NCC(C2=CC3=C(C=C2)NC(=O)CC3)O
Properties
C22H28N2O2
Molar mass 352.478 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Brefonalol is a beta-adrenergic antagonist that reduces heart frequency and blood pressure and dilates blood vessels. It has been studied in around 1990, [1] but is not known to be marketed as of 2021.

Related Research Articles

Neve Shalom Village in Israel

Neve Shalom, also known as Wāħat as-Salām is a cooperative village in Israel, jointly founded by Israeli Jews and Arabs in an attempt to show that the two peoples can live side by side peacefully, as well as to conduct educational work for peace, equality and understanding between the two peoples. The village is located on one of the two Latrun hilltops overlooking the Ayalon Valley, and lies midway between Tel Aviv and Jerusalem. Falling under the jurisdiction of Mateh Yehuda Regional Council, in 2019 it had a population of 323.

Etrigan the Demon Fictional character

Etrigan the Demon is a fictional antihero appearing in American comic books published by DC Comics. Created by Jack Kirby, Etrigan is a demon from Hell who, despite his violent tendencies, usually finds himself allied with the forces of good, mainly because of the alliance between the heroic characters of the DC Universe and Jason Blood, a human to whom Etrigan is bound. Etrigan is commonly depicted as a muscular humanoid creature with orange or yellow skin, horns, red eyes, and pointed, webbed ears, who frequently speaks in rhymes. The character was originally based in Gotham City, leading to numerous team-ups with Batman.

St. Helens (skyscraper)

St Helen's is a commercial skyscraper in London, United Kingdom. It is 118 metres (387 ft) tall and has 23 floors. The postal address is No. 1, Undershaft, though the main entrance fronts onto Leadenhall Street, in the City of London financial district.

Rhythm in Arabic music

Rhythms in Arabic music are rich and very diverse, as they cover a huge region and peoples from Northern Africa to Western Asia. Rhymes are mainly analysed by means of rhythmic units called awzan and iqa'at.

Anjoman-e Hojjatieh, also called The Hojjatieh Society, is a traditionalist Iranian Shi'a lay religious organization that promotes orthodoxy through non-violent evangelism. It was founded in response to the Baháʼí Faith in the 1950s.

Halabi is an Arabic locational surname, or nisba, denoting origin from Aleppo (Halab), Syria, or those who traded with Aleppo residents. Variants of the name include Halaby, Haleb, Halep, and Halepovich. The name may refer to:

Cambridge House

Cambridge House is a Grade I listed former townhouse in central London, England. It sits on the northern side of Piccadilly at number 94, in the fashionable district of Mayfair. As of 2019, the property is being converted into a luxury hotel and seven residences.

Sirat al-Halbiya is a book about the history of Islam in six volumes by Islamic scholar Ali Ibn Burhan-ud-din Halabi.

Rayhāna bint Zayd was a Jewish woman from the Banu Nadir tribe, who is revered by some Muslims as one of the Ummahaatu'l-Mu'mineen, or Mothers of the Faithful - the Wives of Muhammad.

Halbi language

Halbi is an Eastern Indo-Aryan language, transitional between Odia and Marathi. It is spoken by 500,000 people across the central part of India.

Bassam Simon Halabi is a Syrian-born British businessman and property developer.

Suleiman al-Halabi

Suleiman al-Halabi, also spelled Soleyman El-Halaby (1777–1800), was a Kurdish man who assassinated French general Jean-Baptiste Kléber, leader of the French occupation forces in Egypt. He was tortured by burning his hand to the bone before being executed by anal impalement.

Majdi Halabi, alternatively Majdy Halabi or Majdi Halaby, was an Israeli Druze soldier from the village of Daliyat al-Karmel, located on the slopes of Mount Carmel, who disappeared on duty near Haifa in May 2005.

Oppressors–oppressed distinction or dominant–dominated opposition is a political concept. One of the first theorists to use it was Georg Wilhelm Friedrich Hegel, who wrote in his 1802 The German Constitution: "The Catholics had been in the position of oppressors, and the Protestants of the oppressed." Karl Marx made the concept very influential, and it is often considered a fundamental element of Marxist analysis. Some have judged it simplistic. Many authors have adapted it to other contexts, including Marx, Friedrich Engels, Vladimir Lenin, Antonio Gramsci, Simone Weil, Paulo Freire, and others. It has been used in a variety of contexts, including discussions of the bourgeoisie and proletariat, imperialism, and self-determination.

Macitentan

Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH). The other two ERAs marketed as of 2014 are bosentan and ambrisentan. Macitentan is a dual ERA, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ETA and ETB. However, macitentan has a 50-fold increased selectivity for the ETA subtype compared to the ETB subtype. The drug received approval from the U.S. Food and Drug Administration (FDA) on October 13, 2013.

Muhammad Ali al-Halabi was a Syrian politician.

Halabi, Iran village in West Azerbaijan, Iran

Halabi is a village in Solduz Rural District, in the Central District of Naqadeh County, West Azerbaijan Province, Iran. At the 2006 census, its population was 454, in 81 families.

Ponesimod

Ponesimod, sold under the brand name Ponvory, is a medication for the treatment of multiple sclerosis (MS).

General Salah Mohamed Attia Halabi was an Egyptian Army officer. Born in 1937, he commanded an infantry brigade, an infantry division, the Third Army, and commanded the two-division Corps Sized Egyptian expeditionary force to Saudi Arabia during Operation Desert Storm.

Ibrāhīm ibn Muḥammad ibn Ibrāhīm al-Ḥalabī was an Islamic jurist (faqīh) who was born around 1460 in Aleppo, and who died in 1549 in Istanbul. His reputation as one of the most brilliant legists of his time chiefly rests on his work entitled Multaqā al-Abḥur, which became the standard handbook of the Ḥanafī school of Islamic law in the Ottoman Empire.

References

  1. Halabi, A; Endell, W; Halabi, I; Kirch, W (1990). "Hemodynamic effects of brefanolol and propranolol assessed by noninvasive methods in patients with arterial hypertension". Journal of Cardiovascular Pharmacology. 16 (1): 81–6. doi:10.1097/00005344-199007000-00011. PMID   1696669. S2CID   41692901.