Tertatolol

Tertatolol

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C07AA16 ( WHO )
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name (±)-1-(tert-Butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol
CAS Number	83688-84-0  Y
PubChem CID	36920
IUPHAR/BPS	571
ChemSpider	33875  N
UNII	9ZO341YQXP
KEGG	D07182  Y
ChEMBL	ChEMBL434200  N
CompTox Dashboard (EPA)	DTXSID80865735
ECHA InfoCard	100.073.179
Chemical and physical data
Formula	C16H25NO2S
Molar mass	295.44 g·mol−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES CC(C)(C)NCC(COC1=CC=CC2=C1SCCC2)O
InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 N Key:HTWFXPCUFWKXOP-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

Tertatolol (Artex, Artexal, Prenalex) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It was discovered by the French pharmaceutical company Servier and is marketed in Europe. ^[1]

Tertatolol has also been shown to act as a serotonin 5-HT_1A and 5-HT_1B receptor antagonist, similarly to propranolol and pindolol. ^{[2] [3] [4]}

See also

• Hydroxytertatolol

References

1. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN   3-88763-075-0.
2. Langlois M, Brémont B, Rousselle D, Gaudy F (January 1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". European Journal of Pharmacology. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID   8093601.
3. Jolas T, Haj-Dahmane S, Lanfumey L, Fattaccini CM, Kidd EJ, Adrien J, et al. (May 1993). "(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain". Naunyn-Schmiedeberg's Archives of Pharmacology. 347 (5): 453–463. doi:10.1007/bf00166735. PMID   7686633. S2CID   22129922.
4. van Wijngaarden I, Soudijn W, Tulp MT (1997). "5-HT_1A Receptors". In Soudijn W, Olivier B, van Wijngaarden I (eds.). Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. ISBN   0-444-82041-8.