ORG-37684

Last updated
ORG-37684
ORG-37684.svg
Clinical data
Other namesORG37684
Drug class Serotonin 5-HT2 receptor agonist; Serotonin 5-HT2C receptor agonist; Serotonin 5-HT2A receptor agonist
ATC code
  • None
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (3S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
Formula C14H19NO2
Molar mass 233.311 g·mol−1
3D model (JSmol)
  • O(c1c(OC)ccc2c1CCC2)[C@H]3CCNC3
  • InChI=1S/C14H19NO2/c1-16-13-6-5-10-3-2-4-12(10)14(13)17-11-7-8-15-9-11/h5-6,11,15H,2-4,7-9H2,1H3/t11-/m0/s1
  • Key:QDJAYXYEXHVXJV-NSHDSACASA-N
   (verify)

ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, including of the serotonin 5-HT2C, 5-HT2B, and 5-HT2A receptors, in that order of potency. [1] [2] [3] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans. [4] ORG-37684 produces the head-twitch response, a behavioral proxy of psychedelic effects, and hence may be hallucinogenic in humans. [1] The drug was under development for the treatment of major depressive disorder in the 1990s and early 2000s, and reached the preclinical research stage, but development was discontinued and it was never marketed. [5] [6]

Contents

See also

References

  1. 1 2 Vickers SP, Easton N, Malcolm CS, Allen NH, Porter RH, Bickerdike MJ, Kennett GA (2001). "Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists". Pharmacol Biochem Behav. 69 (3–4): 643–652. doi:10.1016/s0091-3057(01)00552-4. PMID   11509227.
  2. ↑ Adams D, Duncton M (2001). "Efficient Synthesis of the 5-Ht2C Receptor Agonist, Org 37684". Synthetic Communications. 31 (13): 2029–2036. doi:10.1081/SCC-100104420. S2CID   83706335.
  3. ↑ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–23. doi:10.1007/s00210-004-0951-4. PMID   15322733. S2CID   8938111.
  4. ↑ Schreiber R, De Vry J (April 2002). "Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26 (3): 441–9. doi:10.1016/s0278-5846(01)00284-6. PMID   11999893. S2CID   25689931.
  5. ↑ "ORG 37684". AdisInsight. 22 January 2007. Retrieved 24 January 2026.
  6. ↑ "Delving into the Latest Updates on Org-37684 with Synapse". Synapse. 24 January 2026. Retrieved 24 January 2026.
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