Ayahuasca is a South American psychoactive brew, traditionally used by Indigenous cultures and folk healers in Amazon and Orinoco basins for spiritual ceremonies, divination, and healing a variety of psychosomatic complaints. Originally restricted to areas of Peru, Brazil, Colombia and Ecuador, in the middle of 20th century it became widespread in Brazil in context of appearance of syncretic religions that uses ayahuasca as a sacrament, like Santo Daime, União do Vegetal and Barquinha, which blend elements of Amazonian Shamanism, Christianity, Kardecist Spiritism, and African-Brazilian religions such as Umbanda, Candomblé and Tambor de Mina, later expanding to several countries across all continents, notably the United States and Western Europe, and, more incipiently, in Eastern Europe, South Africa, Australia, and Japan.
N,N-Dimethyltryptamine is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen.
The Rubiaceae are a family of flowering plants, commonly known as the coffee, madder, or bedstraw family. It consists of terrestrial trees, shrubs, lianas, or herbs that are recognizable by simple, opposite leaves with interpetiolar stipules and sympetalous actinomorphic flowers. The family contains about 13,500 species in about 620 genera, which makes it the fourth-largest angiosperm family. Rubiaceae has a cosmopolitan distribution; however, the largest species diversity is concentrated in the tropics and subtropics. Economically important genera include Coffea, the source of coffee, Cinchona, the source of the antimalarial alkaloid quinine, ornamental cultivars, and historically some dye plants.
Banisteriopsis caapi, also known as, caapi, soul vine, or yagé (yage), is a South American liana of the family Malpighiaceae. It is commonly used as an ingredient of ayahuasca, a decoction with a long history of its entheogenic use and its status as a "plant teacher" among the Indigenous peoples of the Amazon rainforest.
Phalaris arundinacea, or reed canary grass, is a tall, perennial bunchgrass that commonly forms extensive single-species stands along the margins of lakes and streams and in wet open areas, with a wide distribution in Europe, Asia, northern Africa and North America. Other common names for the plant include gardener's-garters and ribbon grass in English, alpiste roseau in French, Rohrglanzgras in German, kusa-yoshi in Japanese, caniço-malhado in Portuguese, and hierba cinta and pasto cinto in Spanish.
Harmala alkaloids are several alkaloids that increase effects of reward system neurotransmitter dopamine by acting as monoamine oxidase inhibitors (MAOIs). These alkaloids are found in the seeds of Peganum harmala, as well as leaves of tobacco and coffee beans. The alkaloids include harmine, harmaline, harmalol, and their derivatives, which have similar chemical structures, hence the name "harmala alkaloids". These alkaloids are of interest for their use in Amazonian shamanism, where they are derived from other plants. Harmine, once known as telepathine and banisterine, is a naturally occurring beta-carboline alkaloid that is structurally related to harmaline, and also found in the vine Banisteriopsis caapi. Tetrahydroharmine is also found in B. caapi and P. harmala. Dr. Alexander Shulgin has suggested that harmine may be a breakdown product of harmaline. Harmine and harmaline are reversible inhibitors of monoamine oxidase A (RIMAs). They can stimulate the central nervous system by inhibiting the metabolism of monoamine compounds such as serotonin and norepinephrine.
Harmine is a beta-carboline and a harmala alkaloid. It occurs in a number of different plants, most notably the Syrian rue and Banisteriopsis caapi. Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a Reversible inhibitor of monoamine oxidase A (RIMA). Harmine does not inhibit MAO-B. Harmine is also known as banisterin, banisterine, telopathin, telepathine, leucoharmine and yagin, yageine.
Harmaline is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partly hydrogenated form of harmine.
Mimosa tenuiflora, syn. Mimosa hostilis, also known as jurema preta, calumbi (Brazil), tepezcohuite (México), carbonal, cabrera, jurema, black jurema, and binho de jurema, is a perennial tree or shrub native to the northeastern region of Brazil and found as far north as southern Mexico, and the following countries: El Salvador, Honduras, Panama, Colombia and Venezuela. It is most often found in lower altitudes, but it can be found as high as 1,000 m (3,300 ft).
The Beneficent Spiritist Center União do Vegetal is a religious society founded on July 22, 1961 in Porto Velho (Rondônia) by José Gabriel da Costa, known as Mestre Gabriel. The UDV seeks to promote peace and to "work for the evolution of the human being in the sense of his or her spiritual development", as is written in its bylaws. The institution today has over 18,000 members, distributed among more than 200 local chapters located in all the states of Brazil, as well as in Peru, Australia, several countries in Europe, and the United States. The translation of União do Vegetal is Union of the Plants referring to the sacrament of the UDV, Hoasca tea, also known as Ayahuasca. This beverage is made by boiling two plants, mariri and chacrona, both of which are native to the Amazon rainforest.
Pharmahuasca is a pharmaceutical version of the entheogenic brew ayahuasca. Traditional ayahuasca is made by brewing the MAOI-containing Banisteriopsis caapi vine with a DMT-containing plant, such as Psychotria viridis. Pharmahuasca refers to a similar combination that uses a pharmaceutical MAOI instead of a plant.
Diplopterys cabrerana is a shrub native to the Amazon Basin, spanning the countries of Brazil, Colombia, Ecuador and Peru. In the Quechua languages it is called chaliponga or chagropanga; in parts of Ecuador it is known as chacruna—a name otherwise reserved for Psychotria viridis.
Psychotria carthagenensis, also known as amyruca, is a South American rainforest understory shrub from the coffee family, Rubiaceae. It grows from the tropics of South America to Mexico.
Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine. The amino acid tryptophan is the biochemical precursor of indole alkaloids.
Acacia obtusifolia, commonly known as stiff-leaf wattle or blunt-leaf wattle, is a perennial tree in subfamily Mimosoideae of family Fabaceae.
Drosera peruensis is a carnivorous plant of the genus Drosera, commonly known as the Peruvian sundew. This Drosera species was first identified in Peru in 2002 by Tânia Regina dos Santos Silva and Mireya D. Correa following work to update the genus Drosera for the reference text, Flora Neotropica..
Callaeum antifebrile is a South American jungle vine of the family Malpighiaceae which occurs predominantly throughout the Upper Amazon basin, and less frequently along the Lower Amazon. Occasionally a component in ayahuasca decoctions, it is used as a folk medicine in some parts of Brazil, often as an antifebrile (anti-fever) remedy.
Changa is a blend of N,N-Dimethyltryptamine (DMT) mixed with a monoamine oxidase inhibitor (MAOI). The addition of MAOIs extends the DMT experience in duration and intensity when compared with smoking DMT freebase alone. Typically, extracts from DMT-containing plants are combined with a blend of different MAOI-containing herbs, such as the ayahuasca vine, and/or leaf or harmala alkaloids from Peganum harmala to create a mix that is 25 to 50% DMT.
