MLD-41

MLD-41

Clinical data
Other names	MLD-41; N1-Methyl-Lysergic Acid Diethylamide; 1-Methyl-LSD; 1-Methyl-N,N-Diethyllysergamide; Methyl-LSD
Routes of administration	Oral
Drug class	Serotonergic psychedelic; Hallucinogen
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
IUPAC name (8β)-N,N-Diethyl-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide
CAS Number	4238-85-1  Y
PubChem CID	165200
ChemSpider	144824  Y
CompTox Dashboard (EPA)	DTXSID00895034
Chemical and physical data
Formula	C21H27N3O
Molar mass	337.467 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N(CC)CC)[C@@H]3/C=C2/c4cccc1c4c(cn1C)C[C@H]2N(C3)C
InChI InChI=1S/C21H27N3O/c1-5-24(6-2)21(25)15-10-17-16-8-7-9-18-20(16)14(12-22(18)3)11-19(17)23(4)13-15/h7-10,12,15,19H,5-6,11,13H2,1-4H3/t15-,19-/m1/s1 Y Key:VQZYKSWQIQANKB-DNVCBOLYSA-N Y
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MLD-41, also known as 1-methyl-LSD, is a derivative of LSD that has about one-third the psychoactive effects. It has been studied in cross-tolerance of LSD. ^{[1] [2] [3]}

Metabolism of other 1-methylated ergoloids to their secondary amine derivatives has been frequently noted in mammals. ^[4]

References

1. Jacob P, Shulgin AT (1994). "Structure-activity relationships of the classic hallucinogens and their analogs" (PDF). NIDA Res Monogr. 146: 74–91. PMID   8742795. Archived from the original (PDF) on August 5, 2023.
2. Hoffer A (1965). "D-Lysergic acid diethylamide (LSD): A review of its present status". Clin Pharmacol Ther. 6: 183–255. doi:10.1002/cpt196562183. PMID   14288188.
3. Abramson HA, Rolo A, Sklarofsky B, Stache J (January 1960). "Production of cross-tolerance to psychosis-producing doses of lysergic acid diethylamide and psilocybin". The Journal of Psychology. 49 (1): 151–4. doi:10.1080/00223980.1960.9916396.
4. Müller-Schweinitzer E, Tapparelli C (March 1986). "Methylergometrine, an active metabolite of methysergide". Cephalalgia: An International Journal of Headache. 6 (1): 35–41. doi:10.1046/j.1468-2982.1986.0601035.x. PMID   3698092. S2CID   5778173.