Voxergolide

Last updated

Voxergolide
Voxergolide.svg
Clinical data
Other namesRU41656
Drug class Dopamine D2 receptor agonist
Identifiers
  • (2R,4R,7R)-6-methyl-4-(methylsulfanylmethyl)-3-oxa-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraene
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C16H20N2OS
Molar mass 288.41 g·mol−1
3D model (JSmol)
  • CN1C[C@@H](O[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC
  • InChI=1S/C16H20N2OS/c1-18-8-11(9-20-2)19-16-12-4-3-5-13-15(12)10(7-17-13)6-14(16)18/h3-5,7,11,14,16-17H,6,8-9H2,1-2H3/t11-,14-,16-/m1/s1
  • Key:GYUHVILBXXBZDS-DJSGYFEHSA-N

Voxergolide (INN Tooltip International Nonproprietary Name; developmental code name RU-41656) is a dopamine receptor agonist of the ergoline family described as an anti-anoxic and anti-ischemic agent which was never marketed. [1] [2] [3] It acts specifically as a dopamine D2 receptor agonist. [4] [3]

References

  1. ↑ Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. William Andrew Publishing. 2013. p. 3460. ISBN   978-0-8155-1856-3 . Retrieved 23 February 2025.
  2. ↑ Negwer M (1994). Organic-chemical Drugs and Their Synonyms: (an International Survey). Akad.-Verlag. p. 1179. ISBN   978-3-05-500156-7 . Retrieved 23 February 2025.
  3. 1 2 Patat A, Klein MJ, Surjus A, Hucher M, Granier J (1991). "RU 41,656 does not reverse the scopolamine-induced cognitive deficit in healthy volunteers". European Journal of Clinical Pharmacology. 41 (3): 225–231. doi:10.1007/BF00315434. PMID   1684155.
  4. ↑ Willig F, Van de Velde D, Laurent J, M'Harzi M, Delacour J (1992). "The Roman strains of rats as a psychogenetic tool for pharmacological investigation of working memory: example with RU 41656". Psychopharmacology. 107 (2–3): 415–424. doi:10.1007/BF02245169. PMID   1352059.
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