MAL-LAD

Last updated

MAL-LAD
MAL-LAD.svg
Clinical data
Other namesMALLAD; METAL-LAD; METALLAD; 6-Methallyl-6-nor-LSD; N,N-Diethyl-6-(2-methylprop-2-en-1-yl)-9,10-didehydroergoline-8β-carboxamide
Drug class Serotonin receptor agonist
ATC code
  • None
Identifiers
  • (6aR,9R)-N,N-Diethyl-7-(2-methylprop-2-en-1-yl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Chemical and physical data
Formula C23H29N3O
Molar mass 363.505 g·mol−1
3D model (JSmol)
  • CCN(C(=O)[C@H]1CN(CC(=C)C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
  • InChI=1S/C23H29N3O/c1-5-25(6-2)23(27)17-10-19-18-8-7-9-20-22(18)16(12-24-20)11-21(19)26(14-17)13-15(3)4/h7-10,12,17,21,24H,3,5-6,11,13-14H2,1-2,4H3/t17-,21-/m1/s1
  • Key:CMBLBLPHJKCTIR-DYESRHJHSA-N

MAL-LAD, or MALLAD, also known as METAL-LAD or METALLAD, as well as 6-methallyl-6-nor-LSD, is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD). [1] [2]

Contents

The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor among others. [1] [2] It is also a dopamine receptor agonist, though unlike other lysergamides, does not show activity at the dopamine D1 and D5 receptors. [2] MAL-LAD does not appear to have been assessed in animal tests of psychedelic-like activity such as drug discrimination. [1]

MAL-LAD was first described in the scientific literature by Andrew Joseph Hoffman of the lab of David E. Nichols at Purdue University by 1987. [1] It was subsequently further described by a group of researchers that included Nichols and other colleagues in 2025. [2]

See also

References

  1. 1 2 3 4 Hoffman AJ (August 1987). Synthesis and pharmacological evaluation of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives (Ph.D. thesis). Purdue University.
  2. 1 2 3 4 Jain MK, Gumpper RH, Slocum ST, Schmitz GP, Madsen JS, Tummino TA, et al. (July 2025). "The polypharmacology of psychedelics reveals multiple targets for potential therapeutics" (PDF). Neuron. doi:10.1016/j.neuron.2025.06.012. PMID   40683247.



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