1D-AL-LAD

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1D-AL-LAD
1D-AL-LAD.svg
Clinical data
Other names1D-AL-LAD; 1-(1,2-Dimethylcyclobutane-1-carbonyl)-AL-LAD; 1-(1,2-Dimethylcyclobutanecarbonyl)-6-allyl-nor-LSD
Routes of
administration 		Oral [1]
Drug class Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
Onset of action Peak: 2–2.5 hours [1]
Duration of action 12 hours [1]
Chemical and physical data
Formula C29H36N3O2
Molar mass 458.626 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C]1CN(CC=C)[C@@H]2Cc3cn(C(=O)C4(C)CCC4C)c5cccc(C2=C1)c35
  • InChI=1S/C29H36N3O2/c1-6-14-31-17-21(27(33)30(7-2)8-3)15-23-22-10-9-11-24-26(22)20(16-25(23)31)18-32(24)28(34)29(5)13-12-19(29)4/h6,9-11,15,18-19,25H,1,7-8,12-14,16-17H2,2-5H3/t19?,25-,29?/m1/s1
  • Key:ACLYLFJYXSFFCC-DOQLBWFESA-N

1D-AL-LAD, also known as 1-(1,2-dimethylcyclobutane-1-carbonyl)-AL-LAD, is a psychedelic drug of the lysergamide family related to AL-LAD. [1] [2] It is thought to be a prodrug of AL-LAD similarly to how 1D-LSD is a prodrug of LSD. [1] 1D-AL-LAD was encountered online as a novel designer drug in 2023 and 2024. [1] It is said to have a dose of 100 to 300 μg orally, a time to peak effects of 2 to 2.5 hours, and a duration of 12 hours. [1] The drug is said have "half the intensity" of LSD, with its effects including psychedelic visuals among others. [1] Although 1D-AL-LAD has reported to have been sold, some or all of the sold product appears to have actually been mislabeled 1T-AL-LAD. [2] [3]

Contents

See also

References

  1. 1 2 3 4 5 6 7 8 "1D-AL-LAD". AIPSIN (in Russian). Retrieved 1 January 2026.
  2. 1 2 Okada Y, Segawa H, Yamamuro T, Kuwayama K, Tsujikawa K, Kanamori T, et al. (April 2025). "Synthesis and analytical characterization of 1-(2-thienoyl)-6-allyl-nor-d-lysergic acid diethylamide (1T-AL-LAD)". Drug Testing and Analysis. 17 (4): 494–501. doi:10.1002/dta.3747. PMID   38922764. Since the end of 2023, a novel compound "1D-AL-LAD" appeared on X (formerly Twitter) and other websites. According to the Wikipedia article, "1D-LSD" is 1-(1,2-dimethylcyclobutanecarbonyl)-LSD (Figure 1c),22 a type of Group A LSD analog. However, there are no reports on this compound, except on Wikipedia. Meanwhile, our group identified 1T-LSD on the blotter paper labeled "1D-LSD". 11 This was the first report of 1T-LSD and false labeling of 1D-LSD. Another group in Japan reported similar results for 1D-LSD and 1T-LSD.12 Additionally, 1,2-dimethylcyclobutanecarboxylic acid (a compound required to obtain 1D-LSD) is only dealt with by a few contract synthesis companies and is expensive. This implies that all or at least a certain percentage of "1D-AL-LAD" could be 1-(2-thienoyl) AL-LAD23 (1T-AL-LAD).
  3. ↑ Tanaka R, Kawamura M, Ito M, Kikura-Hanajiri R (July 2025). "Identification of two lysergic acid diethylamide analogs, 1-(3-(trimethylsilyl) propionyl) lysergic acid diethylamide (1S-LSD) and 1-(2-thienoyl)-6-allyl-nor-d-lysergic acid diethylamide (1T-AL-LAD), in paper sheet products distributed on the internet". Forensic Toxicology. 43 (2): 370–376. doi:10.1007/s11419-025-00718-3. PMID   40180768. Although the synthesized 1T-AL-LAD compound has been characterized previously [20], this is the first study to identify 1T-AL-LAD in the sheet product that was obtained on the internet. Product B was described as containing 1D-AL-LAD, a compound with a 1,2-dimethylcyclobutane- 1-carbonyl group at the N 1 position of LSD. However, as in the case of 1T-LSD (sold as 1D-LSD), it was a compound with a thiophene-2-carbonyl group at the N 1 position of AL- LAD, 1T-AL-LAD. It is necessary to confirm the structure by analysis, since the compound labeled on the product may actually be different one.
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