4-AcO-EPT

Last updated

4-AcO-EPT
4-AcO-EPT.svg
Clinical data
Other names4-Acetoxy-EPT; 4-Acetoxy-N-ethyl-N-propyltryptamine; 4-HO-EPT AC; 4-OH-EPT AC
Routes of
administration 		Oral [1]
Drug class Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • [3-[2-[ethyl(propyl)amino]ethyl]-1H-indol-4-yl] acetate
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C17H24N2O2
Molar mass 288.391 g·mol−1
3D model (JSmol)
  • CCCN(CC)CCC1=CNC2=C1C(=CC=C2)OC(=O)C
  • InChI=1S/C17H24N2O2/c1-4-10-19(5-2)11-9-14-12-18-15-7-6-8-16(17(14)15)21-13(3)20/h6-8,12,18H,4-5,9-11H2,1-3H3
  • Key:VMFRFQVZMZGHOK-UHFFFAOYSA-N

4-AcO-EPT, also known as 4-acetoxy-N-ethyl-N-propyltryptamine, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT (psilacetin). [1] [2] It is the acetate ester of 4-HO-EPT (eprocin) and is thought to act as a prodrug of 4-HO-EPT. [3] [1] [2] Based on online anecdotal reports, 4-AcO-EPT is said to have a dose of 20 to 30 mg orally. [1] It shows reduced affinity and agonistic potency at serotonin receptors, including the serotonin 5-HT2A receptor, compared to 4-HO-EPT. [3] [4] Similarly to 4-HO-EPT, 4-AcO-EPT produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and does so with comparable potency, in line with it being a prodrug. [3] 4-AcO-EPT was encountered as a novel designer drug online in 2018, in Europe in 2020, and in the United States in 2021. [1] [2]

Contents

Society and culture

Canada

4-AcO-EPT is not a controlled substance in Canada as of 2025. [5]

See also

References

  1. 1 2 3 4 5 "4-OH-EPT AC (4-AcO-EPT)". AIPSIN (in Russian). Retrieved 2 January 2026.
  2. 1 2 3 "4-HO-EPT AC (4-AcO-EPT)". AIPSIN (in Russian). Retrieved 2 January 2026.
  3. 1 2 3 Klein AK, Chatha M, Laskowski LJ, Anderson EI, Brandt SD, Chapman SJ, et al. (April 2021). "Investigation of the Structure-Activity Relationships of Psilocybin Analogues". ACS Pharmacology & Translational Science. 4 (2): 533–542. doi:10.1021/acsptsci.0c00176. PMC   8033608 . PMID   33860183.
  4. ↑ Glatfelter GC, Naeem M, Pham DN, Golen JA, Chadeayne AR, Manke DR, et al. (April 2023). "Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice". ACS Pharmacology & Translational Science. 6 (4): 567–577. doi:10.1021/acsptsci.2c00222. PMC   10111620 . PMID   37082754.
  5. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
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