The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs: [1] [2]
Oxypertine is known to show high affinity for the serotonin 5-HT2 and dopamine D2 receptors (Ki = 8.6 nM and 30 nM, respectively) and to also act as a catecholamine depleting agent. [2] [3] Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals. [2] [4]
Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety. [1] [2]
The pertines were developed and initially described in the 1960s and 1970s. [1]