Lidoflazine

Lidoflazine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C08EX01 ( WHO );
Identifiers
	IUPAC name 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide;
CAS Number	3416-26-0 ;
PubChem CID	3926 ;
ChemSpider	3789 ;
UNII	J4ZHN3HBTE ;
KEGG	D04733 ;
CompTox Dashboard (EPA)	DTXSID6045377 ;
ECHA InfoCard	100.020.285
Chemical and physical data
Formula	C30H35F2N3O
Molar mass	491.627 g·mol−1
3D model (JSmol)	Interactive image ;
Melting point	159 to 161 °C (318 to 322 °F)
Solubility in water	Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
	SMILES CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F;
	InChI InChI=1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36) ; Key:ZBIAKUMOEKILTF-UHFFFAOYSA-N ;
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Last updated May 28, 2025

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.^[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Physical properties

Solubility at room temperature

Extracted from^[1]

Solvent	0.01 N		0.1 N
Solvent		%	pH	%	pH
Hydrochloric Acid	0.4	3.0	0.7	1.9
Tartaric Acid	0.3	3.1	1.0	2.5
Citric Acid	0.3	3.1	0.5	2.5
Lactic Acid	0.2	3.4	0.7	2.9
Acetic Acid	0.1	3.5	0.4	3.8

References

1 2 Schaper WK, Xhoneux R, Jageneau AH, Janssen PA (May 1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator" . The Journal of Pharmacology and Experimental Therapeutics. 152 (2): 265–274. doi:10.1016/S0022-3565(25)27319-0. PMID 5944369.

v t e Arylpiperazines
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Naphthylpiperazines	1-Naphthylpiperazine (1-NP) 2-Naphthylpiperazine (2-NP) CSP-2503 F-11,461 S-14,506 S-14671
Quinolinylpiperazines	FPPQ 6-Nitroquipazine Isoquipazine Quipazine
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Lidoflazine

Contents

Physical properties

Solubility at room temperature

References

Further reading