Levodropropizine

Last updated
Levodropropizine
Levodropropizine.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Pharmacokinetic data
Protein binding 11–14%
Excretion 83% via urine within 96 h
Identifiers
  • (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard 100.167.719 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C13H20N2O2
Molar mass 236.315 g·mol−1
3D model (JSmol)
  • O[C@@H](CN2CCN(c1ccccc1)CC2)CO
  • InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1 Yes check.svgY
  • Key:PTVWPYVOOKLBCG-ZDUSSCGKSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system. [1] It does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.

Levopront Levopront levodropropizine5.jpg
Levopront

In September 2021, Korea United Pharm file lawsuits against 15 drug manufacturers as patent infringement protection for its 2017 registered antitussive drug Levotics CR Tab. (levodropropizine). The cases are anchored on violation of its patent for "Method for Preparing Sustained-Release Tablets Containing Levodropropizine." [2] In September 2023, KUP signed a five-year $52.1 million contract with MCQ, a Thai-based pharmaceutical company, for supply of its mucoactive drug, Levotics CR Tab (levodropropizine). [3]

References

  1. De Blasio F, Dicpinigaitis PV, Rubin BK, De Danieli G, Lanata L, Zanasi A (January 2012). "An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome". Cough. 8 (1): 1. doi: 10.1186/1745-9974-8-1 . PMC   3274450 . PMID   22269875.
  2. Chan-hyuk, Kim (September 9, 2021). "Korea United Pharm sues 15 drugmakers to protect cough suppressant's patent". Korea Biomedical Review . Retrieved July 29, 2024.
  3. "Korea United Pharm to supply mucoactive drugs worth $52 million to Thailand". Korea Biomedical Review. September 9, 2023. Retrieved July 29, 2024.