Dibunate

Last updated
Dibunate
Dibunate.png
Clinical data
Trade names Aducin, Becantal, Becantex, Bechisan, Bexedyl, Keuten, Linctussal, Pectoro
ATC code
Identifiers
  • 2,6-Di-tert-butylnaphthalene-1-sulfonic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.035.511 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C18H24O3S
Molar mass 320.45 g·mol−1
3D model (JSmol)
  • O=S(=O)(O)c1c2c(ccc1C(C)(C)C)cc(cc2)C(C)(C)C
  • InChI=1S/C18H24O3S/c1-17(2,3)13-8-9-14-12(11-13)7-10-15(18(4,5)6)16(14)22(19,20)21/h7-11H,1-6H3,(H,19,20,21) Yes check.svgY
  • Key:WBEBQCINXJDZCX-UHFFFAOYSA-N Yes check.svgY
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Dibunate is a cough suppressant. [1] As the sodium salt, it has been marketed under the name Becantyl (in the United Kingdom), Becantex (in continental Europe), or Linctussal with a dosage of 20 to 30 mg, as either syrup or tablets. [2]

Similar to benzonatate, it is a peripherally acting drug. It has not been reported to cause sedation, euphoria, habituation, or respiratory depression, unlike narcotic antitussives such as codeine. It may work by blocking afferent signals in the reflex arc which controls cough. [3] Nausea is rarely seen as an adverse effect. [4]

References

  1. Sevelius H, Colmore JP (1967). "Antitussive effect of ethyl dibunate in patients with chronic cough". Clinical Pharmacology and Therapeutics. 8 (3): 381–4. doi:10.1002/cpt196783381. PMID   5338382.
  2. "To-day's drugs: Cough suppressants". Br Med J. 1 (5391): 1165-1167. May 2, 1964. PMC   1813498 . PMID   14120813.
  3. Simon SW (1957). "A comparative study of two new non-narcotic antitussive drugs". Ohio State Med J. 53 (12): 1426-7. PMID   13493953.
  4. Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 63. ISBN   0-8103-7177-4.