Haloprogin

"Polik" redirects here. For other uses, see Polik (disambiguation).

Haloprogin

Clinical data
Routes of administration	Topical
ATC code	D01AE11 ( WHO )
Legal status
Legal status	US:Not available
Identifiers
IUPAC name 1,2,4-Trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
CAS Number	777-11-7  Y
PubChem CID	3561
DrugBank	DB00793  Y
ChemSpider	3440  Y
UNII	AIU7053OWL
KEGG	D00339  Y
ChEMBL	ChEMBL1289  Y
CompTox Dashboard (EPA)	DTXSID9046865
ECHA InfoCard	100.011.169
Chemical and physical data
Formula	C9H4Cl3IO
Molar mass	361.38 g·mol−1
3D model (JSmol)	Interactive image
Melting point	113.5 °C (236.3 °F)
Solubility in water	Insoluble mg/mL (20 °C)
SMILES Clc1cc(OCC#CI)c(Cl)cc1Cl
InChI InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2 Y Key:CTETYYAZBPJBHE-UHFFFAOYSA-N Y
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Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections. ^[1] It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik.

Action

Haloprogin was previously used in 1% topical creams as an antifungal agent. It was marketed over-the-counter primarily to treat tinea infections of the skin. The mechanism of action is unknown. ^[2]

Haloprogin had a high incidence of side effects including: irritation, burning, vesiculation (blisters), scaling, and itching. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects. ^[3]

References

1. Rudolph RI (December 1979). "Haloprogin as treatment for fungal infections". Clinical and Experimental Dermatology. 4 (4): 548. doi:10.1111/j.1365-2230.1979.tb01656.x. PMID   161212. S2CID   71471801.
2. "Haloprogin". Drugs@FDA. Food and Drug Administration. Archived from the original on September 26, 2006. Retrieved 2007-02-17.
3. "Haloprogin". DrugBank. University of Alberta. Nov 6, 2006. Retrieved 2007-02-17.