Diclazuril

Diclazuril

Clinical data
Trade names	Coxiril, Vecoxan
AHFS/Drugs.com	International Drug Names
ATCvet code	QP51BC03 ( WHO )
Identifiers
IUPAC name 2-(4-Chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile
CAS Number	101831-37-2  Y
PubChem CID	456389
ChemSpider	401855  N
UNII	K110K1B1VE
KEGG	D03794  Y
ChEMBL	ChEMBL284733  N
CompTox Dashboard (EPA)	DTXSID4046787
ECHA InfoCard	100.168.055
Chemical and physical data
Formula	C17H9Cl3N4O2
Molar mass	407.64 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1C(C#N)C2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C=N3)Cl)Cl
InChI InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26) N Key:ZSZFUDFOPOMEET-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

Diclazuril (trade name Vecoxan) is a coccidiostat. ^[1] In 2025 diclazuril has also been reported to interact with tubulin and inhibit its polymerization. ^[2]

See also

• Clazuril
• Ponazuril
• Toltrazuril

References

1. Diaferia M, Veronesi F, Morganti G, Nisoli L, Fioretti DP (August 2013). "Efficacy of toltrazuril 5 % suspension (Baycox®, Bayer) and diclazuril (Vecoxan®, Janssen-Cilag) in the control of Eimeria spp. in lambs". Parasitology Research. 112 (Suppl 1): 163–8. doi: 10.1007/s00436-013-3440-1 . PMID   23756962.
2. Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.