Butoconazole

Butoconazole
Clinical data
Trade names	Gynazole-1, Mycelex-3
AHFS/Drugs.com	Monograph
MedlinePlus	a682012
License data	US DailyMed: Butoconazole ;
Pregnancy; category	AU:B3;
Routes of; administration	Vaginal cream
ATC code	G01AF15 ( WHO );
Legal status
Legal status	US: OTC / Rx-only;
Identifiers
	IUPAC name (RS)-1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole;
CAS Number	64872-76-0 ; 64872-77-1 ;
PubChem CID	47472 ;
DrugBank	DB00639 ;
ChemSpider	43192 ;
UNII	0Q771797PH ;
KEGG	D00880 ;
ChEBI	CHEBI:3240 ;
ChEMBL	ChEMBL1295 ;
CompTox Dashboard (EPA)	DTXSID2048537 ;
Chemical and physical data
Formula	C19H17Cl3N2S
Molar mass	411.77 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES Clc1ccc(cc1)CCC(Sc2c(Cl)cccc2Cl)Cn3ccnc3;
	InChI InChI=1S/C19H17Cl3N2S/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22/h1-5,7-8,10-11,13,16H,6,9,12H2 ; Key:SWLMUYACZKCSHZ-UHFFFAOYSA-N ;
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Last updated July 18, 2025

Butoconazole (trade names Gynazole-1, Mycelex-3) is an imidazole antifungal used in gynecology. It is administered as a vaginal cream.^[1]^[2]

References

↑ Seidman LS, Skokos CK (December 2005). "An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis". Infectious Diseases in Obstetrics and Gynecology. 13 (4): 197–206. doi: 10.1155/2005/453239 . PMC 1784583 . PMID 16338779.
↑ Butoconazole Monograph

External links

"Butoconazole". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on June 28, 2019.

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[1] Seidman LS, Skokos CK (December 2005). "An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis". Infectious Diseases in Obstetrics and Gynecology. 13 (4): 197–206. doi: 10.1155/2005/453239 . PMC 1784583 . PMID 16338779.

[2] Butoconazole Monograph

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