Pentoxyverine

Last updated
Pentoxyverine
Pentoxyverine skeletal.svg
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a606008
Pregnancy
category
  • No studies; contraindicated
Routes of
administration 		Oral, rectal
ATC code
Pharmacokinetic data
Metabolism Hepatic
Elimination half-life 2.3 hours (oral), 3–3.5 hours (rectal)
Excretion Renal
Identifiers
  • 2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopentanecarboxylate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.923 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C20H31NO3
Molar mass 333.472 g·mol−1
3D model (JSmol)
Melting point 90 to 95 °C (194 to 203 °F)
Solubility in water good
  • O=C(OCCOCCN(CC)CC)C2(c1ccccc1)CCCC2
  • InChI=1S/C20H31NO3/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3 Yes check.svgY
  • Key:CFJMRBQWBDQYMK-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Pentoxyverine (rINN) or carbetapentane is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold. It is sold over-the-counter as Solotuss, [1] or in combination with other medications, especially decongestants. One such product is Certuss, a combination of guaifenesin and pentoxyverine. [2] The drug has been available in the form of drops, suspensions and suppositories. [1] [3]

Contents

It was formerly available over-the-counter in United States. However, the U.S. Food & Drug Administration ruled in 1987 that pentoxyverine was not generally recognized as safe and effective and ordered it to be removed from the over-the-counter market. [4]

Uses

The drug is used for the treatment of dry cough associated with conditions such as common cold, bronchitis or sinusitis. Like codeine and other antitussives, it relieves the symptom, but does not heal the illness. [1] No controlled clinical trials regarding the efficiency of pentoxyverine are available. [5] In

Pharmacologists use the substance as a selective agonist at the sigma-1 receptor in animal [6] and in vitro experiments. [7] [8]

Contraindications

Pentoxyverine is contraindicated in persons with bronchial asthma [5] or other kinds of respiratory insufficiency (breathing difficulties), as well as angle-closure glaucoma. No data are available for the use of pentoxyverine during pregnancy, lactation, or children under two years of age, wherefore the drug must not be used under these circumstances. [3]

Antitussive drugs are not useful in patients with extensive phlegm production because they prevent coughing up the phlegm. [5]

Adverse effects

The most common side effects (seen in more than 1% of patients) are upper abdominal (belly) pain, diarrhoea, dry mouth, and nausea or vomiting. Allergic reactions of the skin like itching, rashes, hives and angiooedema are rare. The same is true for anaphylactic shock and convulsions. [3] [9]

Overdose

Overdosage leads to drowsiness, agitation, nausea and anticholinergic effects like tachycardia (high heart rate), dry mouth, blurred vision, glaucoma, or urinary retention. [1] [3] Especially in children, pentoxyverine can cause hypoventilation, [5] but much more seldom than codeine and other opioid antitussives.

The treatment of overdosage aims at the symptoms; there are no specific antidotes available. [3]

Interactions

No interactions have been described at usual doses. It is possible that pentoxyverine can increase the potency of sedative drugs like benzodiazepines, some anticonvulsants and antidepressants, and alcohol. Likewise, some consumer informations warn patients from taking the drug in combination with or up to two weeks after monoamine oxidase inhibitors, which are known to cause potentially fatal reactions in combination with the (chemically only distantly related) antitussive dextromethorphan. [1] [3] [5]

Mechanism of action

Pentoxyverine is believed to suppress the cough reflex in the central nervous system, [1] but the exact mechanism of action is not known with certainty. The drug acts as an antagonist at muscarinic receptors [3] (subtype M1) and as an agonist at sigma receptors (subtype σ1) [6] with an IC50 of 9 nM. [10] Its anticholinergic properties can theoretically relax the pulmonary alveoli and reduce phlegm production. Spasmolytic and local anaesthetic properties have also been described. [5] The clinical relevance of these mechanisms is uncertain.

Pharmacokinetics

The substance is absorbed quickly from the gut and reaches its maximum plasma concentration (Cmax) after about two hours. If applied rectally, Cmax is reached after four hours. The bioavailability of the suppositories, measured as area under the curve (AUC), is about twofold that of oral formulations, due to a first pass effect of over 50%. By far the most important metabolisation reaction is ester hydrolysis, which accounts for 26.3% of the total clearance through the kidneys. Only 0.37% are cleared in form of the original substance. [3] The plasma half life is 2.3 hours for oral formulations and three to 3.5 hours for suppositories. [11] Pentoxyverine is also excreted into the breast milk. [3]

Chemical properties

Pentoxyverine dihydrogen citrate, the salt that is commonly used for oral preparations, is a white to off-white, crystalline powder. It dissolves easily in water or chloroform, but not in benzene, diethyl ether, or petroleum ether. It melts at 90 to 95 °C (194 to 203 °F). [5] Other orally available salts are the hydrochloride and the tannate; [12] suppositories contain the free base. [3]

See also

Related Research Articles

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<span class="mw-page-title-main">Guaifenesin</span> Expectorant medication

Guaifenesin, also known as glyceryl guaiacolate, is an expectorant medication taken by mouth and marketed as an aid to eliminate sputum from the respiratory tract. Chemically, it is an ether of guaiacol and glycerine. It may be used in combination with other medications. A 2014 study found that guaifenesin has no effect on sputum production or clearance in upper respiratory infections.

<span class="mw-page-title-main">Promethazine</span> Pharmaceutical drug

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<span class="mw-page-title-main">Dihydrocodeine</span> Opioid

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<span class="mw-page-title-main">Dextrorphan</span> Psychoactive cough suppressant medication

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<span class="mw-page-title-main">Phenyltoloxamine</span> Chemical compound

Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is available in combination with other drugs such as paracetamol (acetominophen).

<span class="mw-page-title-main">Dextromethorphan</span> Morphinan antitussive and dissociative drug

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<span class="mw-page-title-main">Levorphanol</span> Opioid analgesic drug

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<span class="mw-page-title-main">Opipramol</span> Drug used to treat depressive and anxiety disorders

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<span class="mw-page-title-main">Codeine</span> Opiate and prodrug of morphine used to treat pain

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<span class="mw-page-title-main">Cloperastine</span> Chemical compound

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References

  1. 1 2 3 4 5 6 "Carbetapentane". Drugs.com. Archived from the original on 2008-07-26. Retrieved 2018-01-23.
  2. ↑ "Certuss". Drugs.com.
  3. 1 2 3 4 5 6 7 8 9 10 Jasek W, ed. (2008). Austria-Codex (in German) (63 ed.). Vienna: Österreichischer Apothekerverlag. ISBN   978-3-85200-188-3.
  4. ↑ Shuren J (November 30, 2007). "Technical Amendment: Removes carbetapentane citrate from 21 CFR 310.201(a)(20)" (PDF). Govinfo. Food and Drug Administration. Archived from the original (PDF) on April 6, 2021. Retrieved November 3, 2023.
  5. 1 2 3 4 5 6 7 Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 4 (23rd ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN   978-3-7741-9846-3.
  6. 1 2 Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (January 2004). "Antitussive activity of sigma-1 receptor agonists in the guinea-pig". British Journal of Pharmacology. 141 (2): 233–40. doi:10.1038/sj.bjp.0705605. PMC   1574192 . PMID   14691051.
  7. ↑ Kume T, Nishikawa H, Taguchi R, Hashino A, Katsuki H, Kaneko S, et al. (November 2002). "Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro". European Journal of Pharmacology. 455 (2–3): 91–100. doi:10.1016/S0014-2999(02)02582-7. PMID   12445574.
  8. ↑ "Carbetapentane Citrate CAS#: 23142-01-0". Chemical Book.
  9. ↑ Dootz H, Kuhlmann A, Hoffmann K, eds. (2005). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 24 037. ISBN   978-3-87193-306-6.
  10. ↑ Klein M, Musacchio JM (October 10, 1988). "Dextromethorphan binding sites in the guinea pig brain". Cellular and Molecular Neurobiology. 8 (2): 149–156. doi:10.1007/BF00711241. PMID   3044591. S2CID   33844132.
  11. ↑ Steinhilber D, Schubert-Zsilavecz M, Roth HJ (2005). Medizinische Chemie[Medical Chemistry] (in German). Stuttgart: Deutscher Apothekerverlag. p. 190. ISBN   978-3-7692-3483-1.
  12. ↑ "Pentoxyverine Full Prescribing Information". MIMS .
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