Normethadone

Last updated • 1 min readFrom Wikipedia, The Free Encyclopedia
Normethadone
Normethadone.png
Clinical data
Trade names Cophylac
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 100%
Metabolism liver
Elimination half-life 14 days
Excretion Urine
Identifiers
  • 6-dimethylamino-4,4-diphenyl-hexan-3-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.006.730 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C20H25NO
Molar mass 295.426 g·mol−1
3D model (JSmol)
  • O=C(C(c1ccccc1)(c2ccccc2)CCN(C)C)CC
  • InChI=1S/C20H25NO/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14H,4,15-16H2,1-3H3 Yes check.svgY
  • Key:WCJFBSYALHQBSK-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Normethadone (INN, BAN; brand names Ticarda, Cophylac, Dacartil, Eucopon, Mepidon, Noramidone, Normedon, and others), also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent.[ citation needed ] Normethadone is listed under the Single Convention on Narcotic Drugs 1961 and is a Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams. It has an effective span of action for about 14 days, and is 12 to 20 times stronger than morphine. [2] The salts in use are the hydrobromide (free base conversion ratio 0.785), hydrochloride (0.890), methyliodide (0.675), oxalate (0.766), picrate (0.563), and the 2,6-ditertbutylnapthalindisulphonate (0.480). [3]

See also

Related Research Articles

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References

  1. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. "Quotas - 2014". Diversion Control Division. U.S. Department of Justice, Drug Enforcement Administration. Archived from the original on 2016-03-04. Retrieved 2016-02-27.
  3. Nordegren T (2002). "Normethadone". The A-Z encyclopedia of alcohol and drug abuse. Parkland, Fla.: Brown Walker Press. p. 470. ISBN   978-1-58112-404-0.