TH-030418

Last updated
TH-030418
TH-030418.svg
Names
IUPAC name
7α-[(R)-1-hydroxy-1-methyl-3-(thiophen-3-yl)-propyl]-6,14-endo-ethanotetrahydrooripavine
Identifiers
3D model (JSmol)
  • InChI=1S/C28H35NO4S/c1-25(31,9-8-18-5-4-14-34-18)20-16-26-10-11-28(20,32-3)24-27(26)12-13-29(2)21(26)15-17-6-7-19(30)23(33-24)22(17)27/h4-7,14,20-21,24,30-31H,8-13,15-16H2,1-3H3/t20?,21-,24-,25?,26?,27+,28?/m1/s1
    Key: XHPBFKQABAJWQT-ZAEBSCISSA-N
  • OC1=C(O[C@H]2C(OC)(CC6)C(C(O)(C)CCC7=CC=CS7)CC36[C@@]42CCN5C)C4=C(C[C@H]35)C=C1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

TH-030418 is an extremely potent opioid related to thienorphine. TH-030418 carries about 5,000 times the potency of morphine. [1] [2]

See also

References

  1. ↑ Yu, G; Yan, LD; Li, YL; Wen, Q; Dong, HJ; Gong, ZH (August 2011). "TH-030418: a potent long-acting opioid analgesic with low dependence liability". Naunyn-Schmiedeberg's Archives of Pharmacology. 384 (2): 125–31. doi:10.1007/s00210-011-0652-8. PMID   21594658.
  2. ↑ Wen, Q; Yu, G; Li, YL; Yan, LD; Gong, ZH (October 2011). "Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418". Acta Pharmacologica Sinica. 32 (10): 1215–24. doi:10.1038/aps.2011.83. PMC   4010084 . PMID   21863064.
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