SoRI-9409

Last updated
SoRI-9409
SoRI-9409 Structure.svg
Identifiers
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C29H27ClN2O3
Molar mass 487.00 g·mol−1
3D model (JSmol)
  • C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C=C(C=N6)C8=CC=C(C=C8)Cl
  • InChI=1S/C29H27ClN2O3/c30-21-6-3-17(4-7-21)20-11-19-13-29(34)23-12-18-5-8-22(33)26-24(18)28(29,27(35-26)25(19)31-14-20)9-10-32(23)15-16-1-2-16/h3-8,11,14,16,23,27,33-34H,1-2,9-10,12-13,15H2/t23-,27+,28+,29-/m1/s1
  • Key:WRVDUHKCIPYGNZ-FQYQUSJJSA-N
   (verify)

SoRI-9409 is a mixed mu opioid receptor partial agonist and delta opioid receptor antagonist, used in biomedical research. It produces moderate analgesic effects without development of tolerance and with reduced withdrawal symptoms compared to standard opioid analgesics, [1] as well as showing anti-addictive effects that may be useful in the treatment of alcoholism. [2] [3]

References

  1. ↑ Wells JL, Bartlett JL, Ananthan S, Bilsky EJ (May 2001). "In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence". The Journal of Pharmacology and Experimental Therapeutics. 297 (2): 597–605. PMID   11303048.
  2. ↑ Nielsen CK, Simms JA, Pierson HB, Li R, Saini SK, Ananthan S, Bartlett SE (December 2008). "A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats". Biological Psychiatry. 64 (11): 974–81. doi:10.1016/j.biopsych.2008.07.018. PMC   3888668 . PMID   18774553.
  3. ↑ Nielsen CK, Simms JA, Bito-Onon JJ, Li R, Ananthan S, Bartlett SE (March 2012). "The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking". Addiction Biology. 17 (2): 224–34. doi:10.1111/j.1369-1600.2010.00295.x. PMC   3906128 . PMID   21309957.
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