Fedrilate

Fedrilate
Clinical data
Trade names	Tussefan
ATC code	R05DB14 ( WHO );
Identifiers
	IUPAC name 4-morpholin-4-ylbutan-2-yl 4-phenyloxane-4-carboxylate;
CAS Number	23271-74-1 ;
PubChem CID	31796 ;
ChemSpider	29485 ;
UNII	NT86R8M7J5 ;
KEGG	D07389 ;
ChEMBL	ChEMBL2104591 ;
CompTox Dashboard (EPA)	DTXSID70865087 ;
ECHA InfoCard	100.041.390
Chemical and physical data
Formula	C20H29NO4
Molar mass	347.455 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=C(OC(CCN1CCOCC1)C)C3(c2ccccc2)CCOCC3;
	InChI InChI=1S/C20H29NO4/c1-17(7-10-21-11-15-24-16-12-21)25-19(22)20(8-13-23-14-9-20)18-5-3-2-4-6-18/h2-6,17H,7-16H2,1H3 ; Key:RDEOYUSTRWNWLX-UHFFFAOYSA-N ;
	(verify)

Last updated December 27, 2025

Fedrilate is a centrally acting cough suppressant. It was patented as a mucolytic by UCB in 1971, but was never brought to market in the US.^[1] In the Netherlands, it has been marketed as Tussefan and in combination with guaifenesin as Tussefan expectorans.^[2]

References

↑ USpatent 3567835,Henri Morren,"Mucolytic salts, compositions and process for treating mucus",issued March 2, 1971
↑ Kok J, Oosterveld WJ, Sibilo SR (1979). Pharmacotherapeutisch Vademecum (in Dutch). Bussum: Romen. ISBN 90-228-8006-0.

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[1] USpatent 3567835,Henri Morren,"Mucolytic salts, compositions and process for treating mucus",issued March 2, 1971

[2] Kok J, Oosterveld WJ, Sibilo SR (1979). Pharmacotherapeutisch Vademecum (in Dutch). Bussum: Romen. ISBN 90-228-8006-0.

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