Oxolamine

Oxolamine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	R05DB07 ( WHO );
Identifiers
	IUPAC name N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine;
CAS Number	959-14-8 ;
PubChem CID	13738 ;
DrugBank	DB13216 ;
ChemSpider	13143 ;
UNII	90BEA145GY ;
KEGG	D07387 ;
ChEMBL	ChEMBL1620875 ;
CompTox Dashboard (EPA)	DTXSID5023403 ;
ECHA InfoCard	100.012.267
Chemical and physical data
Formula	C14H19N3O
Molar mass	245.326 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES n1c(onc1c2ccccc2)CCN(CC)CC;
	InChI InChI=1S/C14H19N3O/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3 ; Key:IDCHQQSVJAAUQQ-UHFFFAOYSA-N ;
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Last updated December 27, 2025

Oxolamine is a cough suppressant ^[1] that is available as a generic drug in many jurisdictions.^[2]

Oxolamine also has anti-inflammatory activity, which causes a reduction in irritation of the nerve receptors of the respiratory tract.^[3]

It is mainly used for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis and pertussis.^[3]

Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant. It is listed as a prescription drug in New Zealand legislation. Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflammation.^[4]

References

↑ de Groot AC (2022). "3.357 Oxolamine". Systemic Drugs. Monographs in Contact Allergy. Vol. 4 (First ed.). CRC Press. p. 712. ISBN 978-1-00-054991-1.
↑ "Oxolamine". drugs.com. 19 April 2015. Archived from the original on 20 September 2018. Retrieved 23 January 2018.
1 2 "NCATS Inxight Drugs — OXOLAMINE CITRATE". drugs.ncats.io. Archived from the original on 2022-09-26. Retrieved 2022-09-26.
↑ "Oxolamine". go.drugbank.com. Archived from the original on 2022-09-26. Retrieved 2022-09-26.

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[1] Groot AC (2022). "3.357 Oxolamine". Systemic Drugs. Monographs in Contact Allergy. Vol. 4 (First ed.). CRC Press. p. 712. ISBN 978-1-00-054991-1.

[2] "Oxolamine". drugs.com. 19 April 2015. Archived from the original on 20 September 2018. Retrieved 23 January 2018.

[:0-3] 1 2 "NCATS Inxight Drugs — OXOLAMINE CITRATE". drugs.ncats.io. Archived from the original on 2022-09-26. Retrieved 2022-09-26.

[4] "Oxolamine". go.drugbank.com. Archived from the original on 2022-09-26. Retrieved 2022-09-26.

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