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AHFS/Drugs.com | International Drug Names |
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Pharmacokinetic data | |
Metabolism | N-demethylation [1] |
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ECHA InfoCard | 100.000.332 |
Chemical and physical data | |
Formula | C13H17N3O |
Molar mass | 231.299 g·mol−1 |
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Aminophenazone (or aminopyrine, amidopyrine, Pyramidon) is a non-narcotic analgesic substance. It is a pyrazolone and a derivative of phenazone, which also has anti-inflammatory and antipyretic properties. While inexpensive and effective, especially in the treatment of rheumatism, the drug carries a serious risk of severe and sometimes fatal side-effects, including agranulocytosis.[ citation needed ] While its production and use have been banned in many countries, including France, Thailand, India and Japan, it is still sometimes used in the developing world.[ citation needed ]
A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver-function tests. [1] It is also used in measuring the total body water in the human body system. [2]
Aminophenazone was first synthesized by Friedrich Stolz and Ludwig Knorr in the late nineteenth century, and sold as an anti-fever medicine known as Pyramidon by Hoechst AG from 1897 until its eventual replacement[ when? ] by the safer propyphenazone molecule.
Symptoms of exposure to this compound include: [3]
Agranulocytosis often occurs. Ingestion may cause central nervous system stimulation, vomiting, convulsions, cyanosis, tinnitus, leukopenia, kidney damage and coma. Ingestion may also lead to nausea, mental disturbances, methemoglobinemia, chocolate-colored blood, dizziness, epigastric pain, difficulty in hearing, thready pulse and liver damage.
Other symptoms reported via ingestion include hemolytic anemia, porphyria and severe gastrointestinal bleeding. Bone marrow depression also occurs. Rare eye effects include acute transient myopia.
Chronic symptoms include:
When heated to decomposition this compound emits toxic fumes of nitrogen oxides.
Amidopyrine is metabolized by demethylation and acetylation. Amidopirina metabolites are 4-aminoantipyrine, metilaminoantipirin, rubazonovaya and metilrubazonovaya acid. These acids have a reddish color. At high amidopirine doses, urine can have a reddish brown coloration, due to the presence in the urine of these acid markers. [4]
Hospital Universitario Ramón y Cajal in Madrid, Spain was built as a center for specialized surgery, a panacea for the ills of the health system in Madrid. Locals hence nicknamed it el piramidón. [5]
Santiago Ramón y Cajal was a Spanish neuroscientist, pathologist, and histologist specializing in neuroanatomy and the central nervous system. He and Camillo Golgi received the Nobel Prize in Physiology or Medicine in 1906. Ramón y Cajal was the first person of Spanish origin to win a scientific Nobel Prize. His original investigations of the microscopic structure of the brain made him a pioneer of modern neuroscience.
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Rosa María Díez González is a Spanish politician from Union, Progress and Democracy, UPyD deputy in the Congress of Deputies from 2008 to 2016.
Iker Jiménez Elizari is a Spanish journalist and television host. He is a graduate in sciences of information from the Complutense University of Madrid and the European University of Madrid, and gained prominence directing and presenting, along with his wife and collaborator Carmen Porter, mystery investigation program Milenio 3 in Cadena SER, after which they moved to television with the program Cuarto Milenio in Cuatro. In 2020 he created the YouTube podcast La Estirpe de los Libres, and the same year started presenting the divulgation program Horizonte, initially in Telecinco and later in Cuatro.
Bartonella bacilliformis is a bacterium, Gram negative aerobic, pleomorphic, flagellated, motile, coccobacillary, 2–3 μm long, 0.2–0.5 μm wide, and a facultative intracellular bacterium.
José María Forqué Galindo was a Spanish screenwriter and film director.
Union, Progress and Democracy was a Spanish political party founded in September 2007 and dissolved in December 2020. It was a social-liberal party that rejected any form of nationalism, especially the separatist Basque and Catalan movements. The party was deeply pro-European and wanted the European Union to adopt a federal system without overlap between the European, national and regional governments. It also wanted to replace the State of Autonomies with a much more centralist, albeit still politically decentralized, unitary system as well as substituting a more proportional election law for the current one.
Discografía Completa: Edición Especial Gira 98 is a quadruple album that contains Alejandro Sanz's previous albums, it was edited for the 1998 Tour Más.
α-Ketoisocaproic acid (α-KIC), also known as 4-methyl-2-oxovaleric acid, and its conjugate base and carboxylate, α-ketoisocaproate, are metabolic intermediates in the metabolic pathway for L-leucine. Leucine is an essential amino acid, and its degradation is critical for many biological duties. α-KIC is produced in one of the first steps of the pathway by branched-chain amino acid aminotransferase by transferring the amine on L-leucine onto alpha ketoglutarate, and replacing that amine with a ketone. The degradation of L-leucine in the muscle to this compound allows for the production of the amino acids alanine and glutamate as well. In the liver, α-KIC can be converted to a vast number of compounds depending on the enzymes and cofactors present, including cholesterol, acetyl-CoA, isovaleryl-CoA, and other biological molecules. Isovaleryl-CoA is the main compound synthesized from ɑ-KIC. α-KIC is a key metabolite present in the urine of people with Maple syrup urine disease, along with other branched-chain amino acids. Derivatives of α-KIC have been studied in humans for their ability to improve physical performance during anaerobic exercise as a supplemental bridge between short-term and long-term exercise supplements. These studies show that α-KIC does not achieve this goal without other ergogenicsupplements present as well. α-KIC has also been observed to reduce skeletal muscle damage after eccentrically biased resistance exercises in people who do not usually perform those exercises.
Juanjo Puigcorbé is a Spanish actor. He has appeared in over 100 films and television shows since 1977. He starred in the 1993 film The Window Over the Way, which was entered into the 44th Berlin International Film Festival.
Alejandro Angulo León, better known as Álex Angulo was a Spanish actor who performed in over sixty films during his career spanning more than 30 years.
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The Hospital Universitario Ramón y Cajal is a public general hospital located in the Valverde neighborhood, in Madrid, Spain, part of the hospital network of the Servicio Madrileño de Salud.
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De acuerdo con todo ello, el Ramón y Cajal comenzó a ser esperado como la gran panacea que tenía que resolver gran parte de los problemas hospitalarios madrileños. Por ello, alguien pensó que, siguiendo con los términos médicos, el citado centro venía a ser a la sanidad madrileña como el Piramidón -un antipirético muy utilizado para eliminar los síntomas de la enfermedad, aunque no la enfermedad en sí- a cualquier enfermo. De ahí a que el Centro Ramón y Cajal pasara ser conocido por todos como el Piramidón no medió ni un paso.