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AHFS/Drugs.com | International Drug Names |
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Pharmacokinetic data | |
Metabolism | N-demethylation [1] |
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ECHA InfoCard | 100.000.332 |
Chemical and physical data | |
Formula | C13H17N3O |
Molar mass | 231.299 g·mol−1 |
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Aminophenazone (or aminopyrine, amidopyrine, Pyramidon) is a non-narcotic analgesic substance. It is a pyrazolone and a derivative of phenazone, which also has anti-inflammatory and antipyretic properties. While inexpensive and effective, especially in the treatment of rheumatism, the drug carries a serious risk of severe and sometimes fatal side-effects, including agranulocytosis.[ citation needed ] While its production and use have been banned in many countries, including France, Thailand, India and Japan, it is still sometimes used in the developing world.[ citation needed ]
A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver-function tests. [1] It is also used in measuring the total body water in the human body system. [2]
Aminophenazone was first synthesized by Friedrich Stolz and Ludwig Knorr in the late nineteenth century, and sold as an anti-fever medicine known as Pyramidon by Hoechst AG from 1897 until its eventual replacement[ when? ] by the safer propyphenazone molecule.
Symptoms of exposure to this compound include: [3]
Agranulocytosis often occurs. Ingestion may cause central nervous system stimulation, vomiting, convulsions, cyanosis, tinnitus, leukopenia, kidney damage and coma. Ingestion may also lead to nausea, mental disturbances, methemoglobinemia, chocolate-colored blood, dizziness, epigastric pain, difficulty in hearing, thready pulse and liver damage.
Other symptoms reported via ingestion include hemolytic anemia, porphyria and severe gastrointestinal bleeding. Bone marrow depression also occurs. Rare eye effects include acute transient myopia.
Chronic symptoms include:
When heated to decomposition this compound emits toxic fumes of nitrogen oxides.
Amidopyrine is metabolized by demethylation and acetylation. Amidopirina metabolites are 4-aminoantipyrine, metilaminoantipirin, rubazonovaya and metilrubazonovaya acid. These acids have a reddish color. At high amidopirine doses, urine can have a reddish brown coloration, due to the presence in the urine of these acid markers. [4]
Hospital Universitario Ramón y Cajal in Madrid, Spain was built as a center for specialized surgery, a panacea for the ills of the health system in Madrid. Locals hence nicknamed it el piramidón. [5]
Santiago Ramón y Cajal was a Spanish neuroscientist, pathologist, and histologist specializing in neuroanatomy and the central nervous system. He and Camillo Golgi received the Nobel Prize in Physiology or Medicine in 1906. Ramón y Cajal was the first Spaniard to win a scientific Nobel Prize. His original investigations of the microscopic structure of the brain made him a pioneer of modern neuroscience.
Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine, low blood albumin levels, high blood lipids, and significant swelling. Other symptoms may include weight gain, feeling tired, and foamy urine. Complications may include blood clots, infections, and high blood pressure.
Agustín García Calvo was a Spanish philologist, philosopher, poet, and playwright.
Rosa María Díez González is a Spanish politician from Union, Progress and Democracy, UPyD deputy in the Congress of Deputies from 2008 to 2016.
Propylthiouracil (PTU) is a medication used to treat hyperthyroidism. This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. In a thyrotoxic crisis it is generally more effective than methimazole. Otherwise it is typically only used when methimazole, surgery, and radioactive iodine is not possible. It is taken by mouth.
Contrayerva, or contrajerva, is the medicinal rhizome of various tropical Central American and South American species of Dorstenia in the family Moraceae, mainly Dorstenia contrajerva and the closely related Dorstenia drakena but also Dorstenia brasiliensis. The word contrayerva means “counter herb” in Spanish. It was given this name since a 16th-century description claimed that the leaves of a herb were used by South American Indians to counter the deadly poisonous effect of the same herb when used as an arrow poison. Seventeenth century herbalists and botanists identified this herb as the aromatic root that had been brought from Peru to England by Francis Drake, and claimed that it was an antidote against all kinds of poison. By the late 18th century contrayerva had lost its reputation as an antidote, but it continued to be listed in European and American pharmacopoeias and herbals until the 1920s as a gentle stimulant, tonic and diaphoretic. It is still used in folk medicine in Central and South America.
Bartonella bacilliformis is a bacterium, Gram negative aerobic, pleomorphic, flagellated, motile, coccobacillary, 2–3 μm long, 0.2–0.5 μm wide, and a facultative intracellular bacterium.
José María Forqué Galindo was a Spanish screenwriter and film director.
Union, Progress and Democracy was a Spanish political party founded in September 2007 and dissolved in December 2020. It was a social-liberal party that rejected any form of nationalism, especially the separatist Basque and Catalan movements. The party was deeply pro-European and wanted the European Union to adopt a federal system without overlap between the European, national and regional governments. It also wanted to replace the State of Autonomies with a much more centralist, albeit still politically decentralized, unitary system as well as substituting a more proportional election law for the current one.
α-Ketoisocaproic acid (α-KIC), also known as 4-methyl-2-oxovaleric acid, and its conjugate base and carboxylate, α-ketoisocaproate, are metabolic intermediates in the metabolic pathway for L-leucine. Leucine is an essential amino acid, and its degradation is critical for many biological duties. α-KIC is produced in one of the first steps of the pathway by branched-chain amino acid aminotransferase by transferring the amine on L-leucine onto alpha ketoglutarate, and replacing that amine with a ketone. The degradation of L-leucine in the muscle to this compound allows for the production of the amino acids alanine and glutamate as well. In the liver, α-KIC can be converted to a vast number of compounds depending on the enzymes and cofactors present, including cholesterol, acetyl-CoA, isovaleryl-CoA, and other biological molecules. Isovaleryl-CoA is the main compound synthesized from ɑ-KIC. α-KIC is a key metabolite present in the urine of people with Maple syrup urine disease, along with other branched-chain amino acids. Derivatives of α-KIC have been studied in humans for their ability to improve physical performance during anaerobic exercise as a supplemental bridge between short-term and long-term exercise supplements. These studies show that α-KIC does not achieve this goal without other ergogenic supplements present as well. α-KIC has also been observed to reduce skeletal muscle damage after eccentrically biased resistance exercises in people who do not usually perform those exercises.
Pandemia is a 2006 post-apocalyptic teen novel written by American author Johnathan Rand. The novel depicts a scenario in which bird flu mutates and becomes a global epidemic because of modern transportation methods, eventually causing a universal state of emergency.
Juanjo Puigcorbé is a Spanish actor. He has appeared in over 100 films and television shows since 1977. He starred in the 1993 film The Window Over the Way, which was entered into the 44th Berlin International Film Festival.
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Guadalupe Sabio Buzo is a Spanish scientist and Professor at the Spanish National Cardiovascular Research Centre, which is part of the Carlos III Health Institute. Her research focuses on stress-activated kinases and the development of diseases associated with obesity. She was awarded the Princess of Girona Foundation Scientist Prize in 2012 and selected as one of the Top 100 Women Leaders in Spain in 2017.
Bárbara Elizabeth López Pérez, best known as Bárbara López is a Mexican actress best known for her role as Juliana Valdés in the crime drama television series Love to Death (2018–2019). Her other notable TV roles include Lucero Gutiérrez Vega in the Televisa romantic telenovela Un camino hacia el destino (2016), Érika Ballesteros in the telenovela Vino el amor (2016–2017), and María Cruz in the Televisa's comedy telenovela Papá a toda madre (2017–2018) and Dolores in the Pantaya original series Señorita 89. López is the daughter of renowned Mexican producer Reynaldo López.
The Hospital Universitario Ramón y Cajal is a public general hospital located in the Valverde neighborhood, in Madrid, Spain, part of the hospital network of the Servicio Madrileño de Salud.
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De acuerdo con todo ello, el Ramón y Cajal comenzó a ser esperado como la gran panacea que tenía que resolver gran parte de los problemas hospitalarios madrileños. Por ello, alguien pensó que, siguiendo con los términos médicos, el citado centro venía a ser a la sanidad madrileña como el Piramidón -un antipirético muy utilizado para eliminar los síntomas de la enfermedad, aunque no la enfermedad en sí- a cualquier enfermo. De ahí a que el Centro Ramón y Cajal pasara ser conocido por todos como el Piramidón no medió ni un paso.