Salicylamide

Salicylamide

Clinical data
MedlinePlus	a681004
ATC code	N02BA05 ( WHO ) N02BA55 ( WHO ) (combinations)
Pharmacokinetic data
Excretion	Renal
Identifiers
IUPAC name 2-Hydroxybenzamide
CAS Number	65-45-2  Y
PubChem CID	5147
DrugBank	DB08797  Y
ChemSpider	4963  Y
UNII	EM8BM710ZC
ChEBI	CHEBI:32114  Y
ChEMBL	ChEMBL27577  Y
NIAID ChemDB	018403
CompTox Dashboard (EPA)	DTXSID3021726
ECHA InfoCard	100.000.554
Chemical and physical data
Formula	C7H7NO2
Molar mass	137.138 g·mol−1
3D model (JSmol)	Interactive image
Density	1.33 g/cm3
Solubility in water	Soluble in hot water, ether, alcohol, and chloroform. mg/mL (20 °C)
SMILES O=C(c1ccccc1O)N
InChI InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10) Y Key:SKZKKFZAGNVIMN-UHFFFAOYSA-N Y
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Salicylamide (o-hydroxybenzamide or amide of salicyl) is a non-prescription drug with analgesic and antipyretic properties. ^[1] Its medicinal uses are similar to those of aspirin. ^[2] Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedy PainAid. It was also an ingredient in the over-the-counter pain remedy BC Powder but was removed from the formulation in 2009, and Excedrin used the ingredient from 1960 to 1980 in conjunction with aspirin, acetaminophen, and caffeine. It was used in later formulations of Vincent's powders in Australia as a substitute for phenacetin.

Pure salicylamide is a white or slightly pink crystalline powder

Derivatives

Derivatives of salicylamide include ethenzamide, labetalol, medroxalol, otilonium, oxyclozanide, salicylanilide, niclosamide, and raclopride.

See also

• 4-Aminosalicylic acid
• Mesalazine
• Salsalate

References

1. Borne R, Levi M, Wilson N (2008). "Nonsteroidal Anti-Inflammatory Drugs". In Foye WO, Williams DA (eds.). Foye's Principles of Medicinal Chemistry (6th ed.). Philadelphia London: Lippincott Williams & Wilkins. p. 968. ISBN   978-0-7817-6879-5.
2. "Salicylamide". Dictionary.com. Merriam-Webster's Medical Dictionary. Merriam-Webster, Inc. Retrieved December 31, 2006.

External links

• Safety MSDS data Archived 2016-03-03 at the Wayback Machine