Suxibuzone

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Suxibuzone
Suxibuzone.png
Suxibuzone molecule
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
  • 4-[ [4-butyl-3,5-dioxo-1,2-di(phenyl)pyrazolidin-4-yl]methoxy]-4-oxobutanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.044.056 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C24H26N2O6
Molar mass 438.480 g·mol−1
3D model (JSmol)
  • O=C(O)CCC(=O)OCC2(C(=O)N(c1ccccc1)N(C2=O)c3ccccc3)CCCC
  • InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28) X mark.svgN
  • Key:ONWXNHPOAGOMTG-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone, [1] and is commonly used in horses. [2]

Synthesis

Suxibuzone is synthesized by the following method: [3] Patent: [4] (Precursor: [5] )

Suxibuzone synthesis.svg

Phenylbutazone [50-33-9] (1) is hydroxymethylated with formaldehyde giving ~86% 4-butyl-4-(hydroxymethyl)-1,2-diphenylpyrazolidine-3,5-dione [23111-33-3] (2). This is then esterified with succinic anhydride. [108-30-5] (3) to give (4).

References

  1. ↑ Yasuda Y, Shindo T, Mitani N, Ishida N, Oono F, Kageyama T (1982). "Comparison of the absorption, excretion, and metabolism of suxibuzone and phenylbutazone in humans". Journal of Pharmaceutical Sciences . 71 (5): 565–72. Bibcode:1982JPhmS..71..565Y. doi:10.1002/jps.2600710521. PMID   7097505.
  2. ↑ Sabaté D, Homedes J, Salichs M, Sust M, Monreal L (2009). "Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses". Equine Veterinary Journal . 41 (7): 700–5. doi:10.2746/042516409X464807. PMID   19927590.
  3. ↑ Esteve, J. et al, Quim. Ind. (Madrid), 1971,17, 107.
  4. ↑ Esteve Dr Antonio, DE1936747A1 (1970 to Laboratorios Del Dr. Esteve S.A., Barcelona (Spanien)).
  5. ↑ Dhareshwar, Sundeep S.; Stella, Valentino J. (2010). "A Novel Prodrug Strategy for β-Dicarbonyl Carbon Acids: Syntheses and Evaluation of the Physicochemical Characteristics of C-Phosphoryloxymethyl (POM) and Phosphoryloxymethyloxymethyl (POMOM) Prodrug Derivatives". Journal of Pharmaceutical Sciences. 99 (6): 2711–2723. doi:10.1002/jps.22021.


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