Veterinary oncology

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Mast cell tumor on lip of a dog Mast cell tumor on lip.JPG
Mast cell tumor on lip of a dog

Veterinary oncology is a subspecialty of veterinary medicine that deals with cancer diagnosis and treatment in animals. Cancer is a major cause of death in pet animals. In one study, 45% of the dogs that reached 10 years of age or older died of cancer. [1]

Contents

Skin tumors are the most frequently diagnosed type of tumor in domestic animals for two reasons: 1. constant exposure of animal skin to the sun and external environment, 2. skin tumors are easy to see because they are on the outside of the animal. [2]

Cancer statistics

Male dogs

Type of Cancer % of Total Cancer
Connective Tissue17
Testis16
Skin (Melanoma)14
Mouth and Throat10
Lymphoma10
Bone4
Stomach and Intestines3
Nasal cavity1–2

[3] [4] [5]

Female dogs

Type of Cancer % of Total Cancer
Breast51
Connective Tissue9
Mouth and Throat8
Skin (Melanoma)6
Lymphoma5
Liver and Bile Tracts/ducts2
Bone2

[3] [4] [5]

These statistics, being from the 1960s, may not be an accurate representation of cancer in dogs currently.

Human-animal cancer connections

Companion animals such as dogs and cats suffer from many of the same types of cancer as humans. Cancer research with dogs has helped in the design of clinical trials for cancer therapy for humans. In the spirit of the One Health movement (global collaborative research on human and animal health) such human-animal connections in cancer research could benefit both humans and animals with cancer in the future. [1] [6]

Animals with cancer also sometimes function as animal sentinels that provide an early warning of carcinogens and an environmental health hazard to humans. [7] [8]

Ethical issues

Veterinarians use the HHHHHMM Scale to discuss animal quality of life with pet owners before a euthanasia decision is made for a pet with an incurable disease such as cancer (the letters stand for Hurt Hunger Hydration Hygiene Happiness Mobility and "More good days than bad days"). [9] [10]

Related Research Articles

<span class="mw-page-title-main">Veterinary medicine</span> Deals with the diseases of non-human animals

Veterinary medicine is the branch of medicine that deals with the prevention, management, diagnosis, and treatment of disease, disorder, and injury in non-human animals. The scope of veterinary medicine is wide, covering all animal species, both domesticated and wild, with a wide range of conditions that can affect different species.

<span class="mw-page-title-main">Hemangiosarcoma</span> Medical condition

Hemangiosarcoma is a rapidly growing, highly invasive variety of cancer that occurs almost exclusively in dogs, and only rarely in cats, horses, mice, or humans. It is a sarcoma arising from the lining of blood vessels; that is, blood-filled channels and spaces are commonly observed microscopically. A frequent cause of death is the rupturing of this tumor, causing the patient to rapidly bleed to death.

Neutering, from the Latin neuter, is the removal of a non-human animal's reproductive organ, either all of it or a considerably large part. The male-specific term is castration, while spaying is usually reserved for female animals. Colloquially, both terms are often referred to as fixing. In male horses, castrating is referred to as gelding. An animal that has not been neutered is sometimes referred to as entire or intact.

<span class="mw-page-title-main">Mastocytoma</span> Medical condition

A mastocytoma or mast cell tumor is a type of round-cell tumor consisting of mast cells. It is found in humans and many animal species; it also can refer to an accumulation or nodule of mast cells that resembles a tumor.

<span class="mw-page-title-main">Dog health</span> Health of dogs

The health of dogs is a well studied area in veterinary medicine.

<span class="mw-page-title-main">Lymphoma in animals</span> Type of cancer in animals

Lymphoma (lymphosarcoma) in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. The disease also may occur in the eye, skin, and gastrointestinal tract.

<i>Cheyletiella</i> Genus of mites

Cheyletiella is a genus of mites that live on the skin surface of dogs, cats, and rabbits.

<span class="mw-page-title-main">Mammary tumor</span>

A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are not spayed, but they are found in other animals as well. The mammary glands in dogs and cats are associated with their nipples and extend from the underside of the chest to the groin on both sides of the midline. There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy, and treatment options. The prevalence in dogs is about three times that of women. In dogs, mammary tumors are the second most common tumor over all and the most common tumor in female dogs with a reported incidence of 3.4%. Multiple studies have documented that spaying female dogs when young greatly decreases their risk of developing mammary neoplasia when aged. Compared with female dogs left intact, those spayed before puberty have 0.5% of the risk, those spayed after one estrous cycle have 8.0% of the risk, and dogs spayed after two estrous cycles have 26.0% of the risk of developing mammary neoplasia later in life. Overall, unspayed female dogs have a seven times greater risk of developing mammary neoplasia than do those that are spayed. While the benefit of spaying decreases with each estrous cycle, some benefit has been demonstrated in female dogs even up to 9 years of age. There is a much lower risk in male dogs and a risk in cats about half that of dogs.

<span class="mw-page-title-main">Veterinary dentistry</span> Branch of veterinary medicine

Veterinary dentistry is the field of dentistry applied to the care of animals. It is the art and science of prevention, diagnosis, and treatment of conditions, diseases, and disorders of the oral cavity, the maxillofacial region, and its associated structures as it relates to animals.

A vaccine-associated sarcoma (VAS) or feline injection-site sarcoma (FISS) is a type of malignant tumor found in cats which has been linked to certain vaccines. VAS has become a concern for veterinarians and cat owners alike and has resulted in changes in recommended vaccine protocols. These sarcomas have been most commonly associated with rabies and feline leukemia virus vaccines, but other vaccines and injected medications have also been implicated.

Soft tissue sarcoma refers to a broad group of tumors that originate from connective tissues. They tend to have similar histologic appearance and biological behavior, and can be either benign or malignant. Soft tissue sarcomas can arise in any part of the pet's body but skin and subcutaneous tumors are the most commonly observed. Soft-tissue sarcomas comprise approximately 15% of all skin and subcutaneous tumors in dogs and approximately 7% of all skin and subcutaneous tumors in cats. The variety of different tumors that fall under the category of soft tissue sarcomas includes fibrosarcoma, hemangiopericytoma, liposarcoma, rhabdomyosarcoma, leiomyosarcoma, malignant fibrous histiocytoma, malignant nerve sheath tumors, myxosarcoma, myxofibrosarcoma, mesenchymoma, and spindle cell tumor.

<span class="mw-page-title-main">Cancer in dogs</span>

Cancer is the leading cause of death in dogs. It is estimated that 1 in 3 domestic dogs will develop cancer, which is the same incidence of cancer among humans. Dogs can develop a variety of cancers and most are very similar to those found in humans. Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. Selective breeding of dogs has led certain pure-bred breeds to be at high-risk for specific kinds of cancer.

The most common type of cancers affecting the animal's nose are carcinomas and sarcomas, both of which are locally invasive. The most common sites for metastasis are the lymph nodes and the lungs, but can also include other organs.

Tumors that develop within the liver may be either benign (noncancerous) or malignant (cancerous). Tumors can start in the liver, or spread to the liver from another cancer in the body. Malignant liver tumors have been reported to metastasize to other organs such as regional lymph nodes, lungs, kidneys, pancreas, spleen and others.

The average age at which intestinal tumors are diagnosed ranges between 10–12 years for cats and 6 to 9 years for dogs. There are many different types of intestinal tumors, including lymphoma, adenocarcinoma, mast cell tumor, and leiomyosarcoma.

The most common bone tumor is called osteosarcoma, and typically affects middle-age to older dogs of large and giant breeds. Osteosarcoma is less common in cats. Osteosarcoma is an aggressive cancer that can develop in any bone of the body but the majority is seen in the limbs.

Many types of skin tumors, both benign (noncancerous) and malignant (cancerous), exist in cats and dogs. Approximately 20–40% of primary skin tumors are malignant in dogs and 50–65% are malignant in cats. Not all forms of skin cancer in cats and dogs are caused by sun exposure, but it can happen occasionally. On dogs, the nose and pads of the feet contain sensitive skin and no fur to protect from the sun. Also, cats and dogs with thin or light-colored coats are at a higher risk of sun damage over their entire bodies.

<span class="mw-page-title-main">Cat health</span> Health of domestic cats

The health of domestic cats is a well studied area in veterinary medicine.

<span class="mw-page-title-main">Obesity in pets</span>

Obesity in pets occurs when excessive adipose tissue accumulates in the body, and is generally defined as occurring when an animal's body weight is at least 20% greater than its optimal body weight. Obesity is associated with metabolic and hormonal changes, and can predispose pets to illnesses like orthopedic disease, diabetes, and cancer.

References

  1. 1 2 Withrow, Stephen J. (2007). "Why worry about cancer in pets?". In Withrow, Stephen J.; MacEwen, E. Gregory (eds.). Small Animal Clinical Oncology (4th ed.). Philadelphia: W.B. Saunders. pp. xv–xvii. ISBN   978-0-7216-0558-6.
  2. Tumors of the Skin and Soft Tissues: Introduction, The Merck Veterinary Manual http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/72200.htm&word=neoplasm
  3. 1 2 Veterinary Medicine @ About – information about pets, diseases, vet schools
  4. 1 2 Cancer in Dogs Archived September 2, 2007, at the Wayback Machine
  5. 1 2 Kelsey, J. L.; Moore, A. S.; Glickman, T. (1998). "Epidemiologic Studies of Risk Factors for Cancer in Pet Dogs". Epidemiologic Reviews. 20 (2): 204–17. doi: 10.1093/oxfordjournals.epirev.a017981 . PMID   9919439.
  6. Thamm, D; Dow, S (2009). "How companion animals contribute to the fight against cancer in humans" (PDF). Veterinaria Italiana. 45 (1): 111–20. PMID   20391394.
  7. Rabinowitz, P; Scotch, M; Conti, L (2009). "Human and animal sentinels for shared health risks". Veterinaria Italiana. 45 (1): 23–4. PMC   2818012 . PMID   20148187.
  8. Withrow, Stephen J., and MacEwen, E. Gregory, eds. Small Animal Clinical Oncology. 4th ed. Philadelphia, PA: W.B. Saunders, c2007, pp. 12–15.
  9. The Merck/Merial Manual For Pet Health: The complete health resource for your dog, cat, horse or other pets – in everyday language, eds. Cynthia M. Kahn, Scott Line, Merck & Co., Inc., 2007, ISBN   0-911910-99-9, ISBN   978-0-911910-99-5, p. 1250.
  10. Villalobos, A.E., Quality of Life Scale Helps Make Final Call, Veterinary Practice News, September 2004 in Canine and Feline Geriatric Oncology Honoring the Human-Animal Bond, Blackwell Publishing, Table 10.1, 2006 Adaption: http://www.veterinarypracticenews.com/vet-practice-news-columns/bond-beyond/quality-of-life-scale.aspx

See also