Pelubiprofen

Last updated
Pelubiprofen
Pelubiprofen.svg
Clinical data
Trade names Pelubi
Legal status
Legal status
  • Rx in several countries
Identifiers
  • 2-[4-[(E)-(2-Oxocyclohexylidene)methyl]phenyl]propanoic acid
CAS Number
PubChem CID
DrugBank
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C16H18O3
Molar mass 258.317 g·mol−1
3D model (JSmol)
  • CC(C1=CC=C(C=C1)/C=C/2\CCCCC2=O)C(=O)O
  • InChI=1S/C16H18O3/c1-11(16(18)19)13-8-6-12(7-9-13)10-14-4-2-3-5-15(14)17/h6-11H,2-5H2,1H3,(H,18,19)/b14-10+
  • Key:AUZUGWXLBGZUPP-GXDHUFHOSA-N

Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis. [1]

Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia, [2] among other countries.

Research

Pelubiprofen is being studied for use in combination with eperisone. [3]

Because pelubiprofen has low water solubility, development of salt formulations with better solubility are being studied. [4]

Related Research Articles

<span class="mw-page-title-main">Moxibustion</span> Traditional Chinese medical practice

Moxibustion is a traditional Chinese medicine therapy which consists of burning dried mugwort on particular points on the body. It plays an important role in the traditional medical systems of China, Japan, Korea, Vietnam, and Mongolia. Suppliers usually age the mugwort and grind it up to a fluff; practitioners burn the fluff or process it further into a cigar-shaped stick. They can use it indirectly, with acupuncture needles, or burn it on the patient's skin.

<span class="mw-page-title-main">Transdermal patch</span> Adhesive patch used to deliver medication through the skin

A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. An advantage of a transdermal drug delivery route over other types of medication delivery is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin is a very effective barrier; as a result, only medications whose molecules are small enough to penetrate the skin can be delivered by this method. The first commercially available prescription patch was approved by the U.S. Food and Drug Administration in December 1979. These patches administered scopolamine for motion sickness.

<span class="mw-page-title-main">Oxymorphone</span> Opioid analgesic drug

Oxymorphone is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. The elimination half-life of oxymorphone is much faster intravenously, and as such, the drug is most commonly used orally. Like oxycodone, which metabolizes to oxymorphone, oxymorphone has a high potential to be abused.

<span class="mw-page-title-main">Traditional Korean medicine</span> Traditional medicine practiced in Korea

Traditional Korean medicine refers to the forms of traditional medicine practiced in Korea.

<span class="mw-page-title-main">Korean comedy</span>

Korean comedy is the art of comedy, either enacted on stage, or within other media forms in the Korean language. It is not limited by country, so long as the actor has Korean roots.

<span class="mw-page-title-main">Methocarbamol</span> Medication for musculoskeletal pain

Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. It may be used together with rest, physical therapy, and pain medication. It is less preferred in low back pain. It has limited use for rheumatoid arthritis and cerebral palsy. Effects generally begin within half an hour. It is taken by mouth or injection into a vein.

<span class="mw-page-title-main">Kwon Sang-woo</span> South Korean actor

Kwon Sang-woo is a South Korean actor. He rose to stardom in 2003 with the romantic comedy film My Tutor Friend and the melodrama series Stairway to Heaven.

<span class="mw-page-title-main">Daewon Foreign Language High School</span> Private school in Seoul, South Korea

Daewon Foreign Language High School, sometimes Daewon FLHS or DFLHS, is a private preparatory school located in Seoul, South Korea.

Pramocaine is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

The National Academy of Sciences of the Republic of Korea (Korean: 대한민국학술원), is the senior national organization of distinguished Korean scientists and scholars. It was founded to promote learning and research in all areas of sciences by conferring membership and preferential treatment to those who have made outstanding contributions to the advancement of sciences and learning. The Academy consists of 150 Fellows who are selected by their peers for their contributions to the sciences and education.

<i>Prince Daewon</i> 1968 South Korean film

Prince Daewon (Korean: 대원군) is a 1968 South Korean film directed by Shin Sang-ok. It was chosen as Best Film at the Grand Bell Awards.

<i>Conspiracy in the Court</i> South Korean TV series or program

Conspiracy in the Court, is a 2007 South Korean historical drama broadcast on KBS2. The mystery thriller revolves around a murder case set in Hansung, the capital of Korea during the latter years of the Joseon dynasty when the nation was experiencing a rapid influx of western influences. Featuring a band of newcomers in the leading roles, Conspiracy in the Court entails a story of four young visionary idealists and King Jeongjo, Joseon's popular 22nd monarch who fought for commoners' rights and bureaucratic reformation. Despite low ratings averaging 6.00%, it was lauded for its high standard of content and art direction.

<span class="mw-page-title-main">Jaseng Hospital of Oriental Medicine</span> Hospital in Seoul, South Korea

Jaseng Hospital of Korean Medicine is a network of hospitals for non-invasive treatment of spine and joint disorders in South Korea. It was designated as a 'Spine Specialized Oriental Medical Hospital' by the Korea Ministry of Health and also designated as a 'Health Tour' hospital for foreigners by the Korean Health Industry Development Institute (KHIDI).

<span class="mw-page-title-main">Yoon Jong-shin</span> South Korean singer and record producer

Yoon Jong-shin is a South Korean singer-songwriter, record producer, and the CEO of Mystic Story.

<span class="mw-page-title-main">Lee Sang-yeob</span> South Korean actor

Lee Sang-yeob is a South Korean actor. He is best known for starring in the sitcom Living Among the Rich (2011–12), the melodrama The Innocent Man (2012), the period drama Jang Ok-jung, Living by Love (2013), and the fantasy drama While You Were Sleeping (2017). Lee was cast in his first leading role in the weekend drama A Little Love Never Hurts (2013). He recently gained immense recognition for portraying the role of Yoon Gyu-jin in the weekend drama Once Again (2020).

<span class="mw-page-title-main">Jin Kyung</span> South Korean actress

Jin Kyung is a South Korean actress.

<i>Blood</i> (South Korean TV series) 2015 South Korean television series

Blood is a 2015 South Korean television series starring Ahn Jae-hyun, Ji Jin-hee, Koo Hye-sun, and Son Soo-hyun. It aired on KBS2 from February 16 to April 21, 2015 on Mondays and Tuesdays at 22:00 for 20 episodes.

<i>Go Back</i> (TV series) South Korean television series

Go Back is a 2017 South Korean television series starring Son Ho-jun and Jang Na-ra. It premiered on October 13 to November 18, 2017, and aired every Friday and Saturday at 23:00 (KST) on KBS2.

<i>Doctor John</i> (TV series) 2019 South Korean television series

Doctor John is a 2019 South Korean television series starring Ji Sung, Lee Se-young, Lee Kyu-hyung, and Hwang Hee. It is based on the Japanese novel On Hand of God by Yo Kusakabe and aired on SBS from July 19 to September 7, 2019.

<span class="mw-page-title-main">Lee Sang-yi (actor)</span> South Korean actor (born 1991)

Lee Sang-yi is a South Korean actor, musical actor and singer. He is best known for his roles in Once Again (2020), Youth of May (2021), and Hometown Cha-Cha-Cha (2021). As a singer, he is best known for being a member of the vocal group MSG Wannabe.

References

  1. ↑ "Pelubiprofen". AdisInsight.
  2. ↑ "Daewon Pharm wins $3 million deal to export Pelubi to Indonesia". Korea Biomedial Review. September 26, 2023.
  3. ↑ "(Eperisone + pelubiprofen) by Daewon Pharmaceutical for Low Back Pain: Likelihood of Approval". pharmaceutical-technology.com. 5 June 2023.
  4. ↑ Park, Ji Yeon; Oh, Dong Ho; Park, Sang-Wook; Chae, Bo Ram; Kim, Chul Woo; Han, Sang Heon; Shin, Hyeon Jong; Yeom, Soo Bin; Lee, Da Yeong; Park, Min Kyu; Park, Sang-Eun; Park, Jun-Bom; Lee, Kyung-Tae (2021). "Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption". Pharmaceutics. 13 (5): 745. doi: 10.3390/pharmaceutics13050745 . PMC   8158122 . PMID   34070062.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.