Anime is hand-drawn and computer-generated animation originating from Japan. Outside of Japan and in English, anime refers specifically to animation produced in Japan. However, in Japan and in Japanese, anime describes all animated works, regardless of style or origin. Animation produced outside of Japan with similar style to Japanese animation is commonly referred to as anime-influenced animation.
Japan is an island country in East Asia. It is situated in the northwest Pacific Ocean and is bordered on the west by the Sea of Japan, extending from the Sea of Okhotsk in the north toward the East China Sea, Philippine Sea, and Taiwan in the south. Japan is a part of the Ring of Fire, and spans an archipelago of 6852 islands covering 377,975 square kilometers (145,937 sq mi); the five main islands are Hokkaido, Honshu, Shikoku, Kyushu, and Okinawa. Tokyo is the nation's capital and largest city, followed by Yokohama, Osaka, Nagoya, Sapporo, Fukuoka, Kobe, and Kyoto.
Japanese is spoken as a native language by about 128 million people, primarily Japanese people and primarily in Japan, the only country where it is the national language. Japanese belongs to the Japonic or Japanese-Ryukyuan language family. There have been many attempts to group the Japonic languages with other families such as the Ainu, Austroasiatic, Koreanic, and the now-discredited Altaic, but none of these proposals has gained widespread acceptance.
Tokyo, officially the Tokyo Metropolis, is the capital and most populous city of Japan. Formerly known as Edo, its metropolitan area is the most populous in the world, with an estimated 37.468 million residents as of 2018; the city proper has a population of 13.99 million people. Located at the head of Tokyo Bay, the prefecture forms part of the Kantō region on the central coast of Honshu, Japan's largest island. Tokyo serves as Japan's economic center and is the seat of both the Japanese government and the Emperor of Japan.
World War II or the Second World War, often abbreviated as WWII or WW2, was a global conflict that lasted from 1939 to 1945. The vast majority of the world's countries, including all of the great powers, fought as part of two opposing military alliances: the Allies and the Axis. Many participants threw their economic, industrial, and scientific capabilities behind this total war, blurring the distinction between civilian and military resources. Aircraft played a major role, enabling the strategic bombing of population centres and the only two nuclear weapons ever used in war.
The attack on Pearl Harbor was a surprise military strike by the Imperial Japanese Navy Air Service upon the United States against the naval base at Pearl Harbor in Honolulu, Territory of Hawaii, just before 8:00 a.m. on Sunday, December 7, 1941. The United States was a neutral country at the time; the attack led to its formal entry into World War II the next day. The Japanese military leadership referred to the attack as the Hawaii Operation and Operation AI, and as Operation Z during its planning.
The Empire of Japan, also known as the Japanese Empire or Imperial Japan, was a historical nation-state and great power that existed from the Meiji Restoration in 1868 until the enactment of the post-World War II 1947 constitution and subsequent formation of modern Japan. It encompassed the Japanese archipelago and several colonies, protectorates, mandates, and other territories.
ATC code M01Anti-inflammatory and antirheumatic products is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup M01 is part of the anatomical group M Musculo-skeletal system.
ATC code M02Topical products for joint and muscular pain is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup M02 is part of the anatomical group M Musculo-skeletal system.
The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method.
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins.
The Nenitzescu indole synthesis is a chemical reaction that forms 5-hydroxyindole derivatives from benzoquinone and β-aminocrotonic esters.
Sultamicillin, sold under the brand name Unasyn among others, is an oral form of the penicillin antibiotic combination ampicillin/sulbactam. It is used for the treatment of bacterial infections of the upper and lower respiratory tract, the kidneys and urinary tract, skin and soft tissues, among other organs. It contains esterified ampicillin and sulbactam.
Flurbiprofen is a member of the phenylalkanoic acid derivative family of nonsteroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic as well as orally for arthritis or dental pain. Side effects are analogous to those of ibuprofen.
Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) of the heterocyclic acetic acid derivative class. It is used primarily to reduce hormones that cause pain, swelling, tenderness, and stiffness in conditions such as osteoarthritis and rheumatoid arthritis, including juvenile rheumatoid arthritis. In the United States it is marketed as Tolectin and comes as a tablet or capsule.
Proglumetacin is a nonsteroidal anti-inflammatory drug (NSAID). It is metabolized in the body to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. It is manufactured by Merck KGaA under the tradename Emflex, and is available in the UK and other countries as a prescription-only drug.
Pravadoline (WIN 48,098) is an antinflammatory and analgesic drug with an IC50 of 4.9 μM and a Ki of 2511 nM at CB1, related in structure to nonsteroidal anti-inflammatory drugs (NSAIDs) such as indometacin. It was developed in the 1980s as a new antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).
Brazilian tea culture has its origins in the infused beverages, or chás, made by the indigenous cultures of the Amazon region and the Rio da Prata basin. It has evolved since the Portuguese colonial period to include imported varieties and tea-drinking customs. There is a popular belief in Brazil that Brazilians, especially the urban ones, have a greater taste for using sugar in teas than in other cultures, being unused to unsweetened drinks.
Glucametacin is a non-steroidal anti-inflammatory drug used for the treatment of mild or moderate pain associated with rheumatoid arthritis, osteoarthritis, and other rheumatological disorders. It has analgesic and anti-inflammatory effects.
