Fenclofenac

Fenclofenac

Names
Preferred IUPAC name [2-(2,4-Dichlorophenoxy)phenyl]acetic acid
Identifiers
CAS Number	34645-84-6
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL15677
ChemSpider	58860
ECHA InfoCard	100.047.373
PubChem CID	65394
UNII	Y01JW64D01  Y
CompTox Dashboard (EPA)	DTXSID6048830
InChI InChI=1S/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18) Key: IDKAXRLETRCXKS-UHFFFAOYSA-N InChI=1/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18) Key: IDKAXRLETRCXKS-UHFFFAOYAG
SMILES OC(=O)Cc1ccccc1Oc2ccc(Cl)cc2Cl
Properties
Chemical formula	C14H10Cl2O3
Molar mass	297.1 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Fenclofenac is a nonsteroidal anti-inflammatory drug (NSAID) previously used in rheumatism. It has mild immunosuppressive effects ^[1] and may displace thyroid hormone from its binding protein. ^{[2] [3]} It can also cause lichen planus. ^[4]

Due to its side effects it was withdrawn from the UK and US in the 1980s.

References

1. Spiers EM, Watson NT, Beck JS, Chapman IV, Dettmar PW (November 1993). "The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation". Int. J. Immunopharmacol. 15 (8): 865–9. doi:10.1016/0192-0561(93)90003-h. PMID   7902830.
2. Allen PA, Taylor RT (December 1980). "Fenclofenac and thyroid function tests". Br Med J. 281 (6255): 1642. doi:10.1136/bmj.281.6255.1642. PMC   1715072 . PMID   7448557.
3. Taylor R, Clark F, Griffiths ID, Weeke J (October 1980). "Prospective study of effect of fenclofenac on thyroid function tests". Br Med J. 281 (6245): 911–2. doi:10.1136/bmj.281.6245.911. PMC   1714224 . PMID   7427506.
4. Ferguson MM, Wiesenfeld D, MacDonald DG (1984). "Oral mucosal lichenoid eruption due to fenclofenac". J Oral Med. 39 (1): 39–40. PMID   6232357.