Niflumic acid

Niflumic acid

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M01AX02 ( WHO ) M02AA17 ( WHO )
Pharmacokinetic data
Elimination half-life	2.5 hr [1]
Identifiers
IUPAC name 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
CAS Number	4394-00-7  Y
PubChem CID	4488
IUPHAR/BPS	2439
ChemSpider	4333  N
UNII	4U5MP5IUD8
KEGG	D08275  Y
ChEMBL	ChEMBL63323  N
CompTox Dashboard (EPA)	DTXSID1023368
ECHA InfoCard	100.022.289
Chemical and physical data
Formula	C13H9F3N2O2
Molar mass	282.222 g·mol−1
3D model (JSmol)	Interactive image
Melting point	204 °C (399 °F)
SMILES C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
InChI InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) N Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels. ^[2] It has also been reported to act on GABA-A ^[3] and NMDA channels ^[4] and to block T-type calcium channels. ^[5]

References

1. "Half life". Drug Bank. Retrieved 15 July 2011.
2. Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC   2215658 . PMID   6736917.
3. Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". Molecular Pharmacology. 64 (3): 753–63. doi:10.1124/mol.64.3.753. PMID   12920213.
4. Lerma J, Martín del Río R (February 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology. 41 (2): 217–22. doi:10.1016/S0026-895X(25)08859-5. PMID   1371581.
5. Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (June 2012). "Niflumic acid blocks native and recombinant T-type channels". Journal of Cellular Physiology. 227 (6): 2542–55. doi:10.1002/jcp.22992. PMC   4146346 . PMID   21898399.