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| Other names | 5-spiro-(2'-ethyl-3'-5'-dimethyl-cyclopentyl)barbituric acid |
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| Formula | C12H18N2O3 |
| Molar mass | 238.287 g·mol−1 |
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Spirobarbital is a barbiturate derivative developed by Eli Lilly in the 1940s. [1] It has hypnotic and sedative effects, and has a moderate potential for abuse. [2]
Eli Lilly (1839–1898) was the founder of Eli Lilly and Company.
Eli Lilly and Company is an American pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by, and named after, Colonel Eli Lilly, a pharmaceutical chemist and veteran of the American Civil War.
Nizatidine is a histamine H2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
Drotrecogin alfa (activated) is a recombinant form of human activated protein C that has anti-thrombotic, anti-inflammatory, and profibrinolytic properties. Drotrecogin alpha (activated) belongs to the class of serine proteases. Drotrecogin alfa has not been found to improve outcomes in people with severe sepsis. The manufacturer's aggressive strategies in marketing its use in severe sepsis have been criticized. On October 25, 2011, Eli Lilly & Co. withdrew Xigris from the market after a major study showed no efficacy for the treatment of sepsis.
Secobarbital is a short-acting barbiturate derivative drug that was patented in 1934 in the United States. It possesses anaesthetic, anticonvulsant, anxiolytic, sedative, and hypnotic properties. In the United Kingdom, it was known as quinalbarbitone. It is the most frequently used drug in physician-assisted suicide within the United States. Secobarbital is considered to be an obsolete sedative-hypnotic, and as a result, it has largely been replaced by the benzodiazepine family. Seconal was widely abused, known on the street as "red devils" or "reds".
Eli Lilly was an American soldier, pharmacist, chemist, and businessman who founded the Eli Lilly and Company pharmaceutical corporation. Lilly enlisted in the Union Army during the American Civil War and recruited a company of men to serve with him in the 18th Independent Battery Indiana Light Artillery. He was later promoted to major and then colonel, and was given command of the 9th Regiment Indiana Cavalry. Lilly was captured in September 1864 and held as a prisoner of war until January 1865. After the war, he attempted to run a plantation in Mississippi, but it failed and he returned to his pharmacy profession after the death of his first wife. Lilly remarried and worked with business partners in several pharmacies in Indiana and Illinois before opening his own business in 1876 in Indianapolis. Lilly's company manufactured drugs and marketed them on a wholesale basis to pharmacies. Lilly's pharmaceutical firm proved to be successful and he soon became wealthy after making numerous advances in medicinal drug manufacturing. Two of the early advances he pioneered were creating gelatin capsules to contain medicines and developing fruit flavorings. Eli Lilly and Company became one of the first pharmaceutical firms of its kind to staff a dedicated research department and put into place numerous quality-assurance measures.
Eli Lilly, sometimes referred to as Eli Lilly Jr. to distinguish him from his grandfather of the same name, was an American pharmaceutical industrialist and philanthropist from Indianapolis, Indiana, United States. During his tenure as head of Eli Lilly and Company, which was founded by his grandfather, the company grew from a successful, family-owned business into a modern corporation and industry leader. Lilly served as the company president (1932–1948), chairman of the board of directors, and honorary chairman of the board.
Lilly Endowment Inc., headquartered in Indianapolis, Indiana, is one of the world's largest private philanthropic foundations and among the largest endowments in the United States. It was founded in 1937 by Josiah K. Lilly Sr. and his sons, Eli Jr. and Josiah Jr. (Joe), with an initial gift of Eli Lilly and Company stock valued at $280,000 USD. As of 2020, its total assets were worth $21 billion.
Josiah Kirby Lilly Sr., nicknamed "J. K.," was an American businessman, pharmaceutical industrialist, and philanthropist who became president and chairman of the board of Eli Lilly and Company, the pharmaceutical firm his father, Colonel Eli Lilly, founded in 1876. Josiah, the colonel's sole heir, began working at his father’s company at the age of fourteen. He graduated from the Philadelphia College of Pharmacy and Science and became superintendent of the Lilly laboratories in 1882 and company president in 1898. Under his leadership, the company introduced standardized manufacturing processes, expanded its sales force, and increased its research efforts to develop new drugs. Eli Lilly and Company grew into one of the largest and most influential pharmaceutical corporations in the world, and the largest corporation in Indiana. Lilly’s eldest son, Eli Jr., succeeded him as president in 1932. His younger son, Josiah Jr. ("Joe"), succeeded Eli as company president in 1948. J. K. served as chairman of the board from 1932 until his death in 1948.
Eli Lilly and Company v. Medtronic, Inc., 496 U.S. 661 (1990), is a United States Supreme Court case related to patent infringement in the medical device industry. It held that 35 U.S.C. § 271(e)(1) of United States patent law exempted premarketing activity conducted to gain approval of a device under the Federal Food, Drug, and Cosmetic Act from a finding of infringement.
Crotylbarbital, also known as crotarbital, is a barbiturate derivative developed by Eli Lilly in the 1930s It has sedative and hypnotic effects, and was used for the treatment of insomnia until it was replaced by newer alternative drugs with less side effects and lower risk of overdose.
Eli Bridge Company is a family-owned amusement ride manufacturer headquartered in Jacksonville, Illinois, U.S.
Lasmiditan, sold under the brand name Reyvow, is a medication used for the acute treatment of migraine with or without aura in adults. It is not useful for prevention. It is taken by mouth.
Elijah Matthew "Eli" Craig is an American film director, screenwriter, and actor. He is best known for writing and directing the cult horror comedy film Tucker & Dale vs Evil.
Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and was under development by Eli Lilly for attention-deficit disorder (ADD) and as an antidepressant treatment. It was in phase III clinical trials, in 2012, for major depressive disorder, but failed to get approval.
May Cohen, OC is a Canadian physician and educator. She is best known for initiating the creation of a women’s health curriculum in Ontario medical schools and for her work as a women’s health advocate.
Flumezapine is an abandoned, investigational antipsychotic drug that was studied for the treatment of schizophrenia. Flumezapine failed clinical trials due to concern for liver and muscle toxicity. Flumezapine is structurally related to the common antipsychotic olanzapine—a point that was used against its manufacturer, Eli Lilly and Company, in a lawsuit in which generic manufacturers sought to void the patent on brand name olanzapine (Zyprexa). Although flumezapine does not differ greatly from olanzapine in terms of its structure, the difference was considered to be non-obvious, and Eli Lilly's patent rights on Zyprexa were upheld.
Bamlanivimab is a monoclonal antibody developed by AbCellera Biologics and Eli Lilly as a treatment for COVID-19. The medication was granted an emergency use authorization (EUA) by the US Food and Drug Administration (FDA) in November 2020, and the EUA was revoked in April 2021.
Bamlanivimab/etesevimab is a combination of two monoclonal antibodies, bamlanivimab and etesevimab, administered together via intravenous infusion as a treatment for COVID-19. Both types of antibody target the surface spike protein of SARS‑CoV‑2.
Bebtelovimab is a monoclonal antibody developed by AbCellera and Eli Lilly as a treatment for COVID-19.
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