Cinolazepam

Not to be confused with cinazepam, clonazepam, or camazepam.

Cinolazepam

Clinical data
Trade names	Gerodorm 40mg
AHFS/Drugs.com	cinolazepam
Dependence liability	High
Addiction liability	Medium
Routes of administration	Oral
ATC code	N05CD13 ( WHO )
Legal status
Legal status	US:Unscheduled EU:Prescription drug
Pharmacokinetic data
Bioavailability	90–100%
Metabolism	Hepatic
Onset of action	30 minutes to 1 hour
Elimination half-life	9 hours
Duration of action	9 hours
Excretion	Renal
Identifiers
IUPAC name (RS)-3-[9-Chloro-6-(2-fluorophenyl)-4-hydroxy-3-oxo-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-2-yl]propanenitrile
CAS Number	75696-02-5  Y
PubChem CID	3033621
DrugBank	DB01594  Y
ChemSpider	2298251  Y
UNII	68P0556B0U
KEGG	D07328  Y
ChEBI	CHEBI:59514  Y
ChEMBL	ChEMBL2104926  N
CompTox Dashboard (EPA)	DTXSID30868372
Chemical and physical data
Formula	C18H13ClFN3O2
Molar mass	357.77 g·mol−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES FC1=CC=CC=C1C2=NC(C(N(CCC#N)C3=C2C=C(C=C3)Cl)=O)O
InChI InChI=1S/C18H13ClFN3O2/c19-11-6-7-15-13(10-11)16(12-4-1-2-5-14(12)20)22-17(24)18(25)23(15)9-3-8-21/h1-2,4-7,10,17,24H,3,9H2 Y Key:XAXMYHMKTCNRRZ-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Cinolazepam ^[1] (marketed under the brand name Gerodorm) ^[2] is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Due to its strong sedative properties, it is primarily used as a hypnotic.

It was patented in 1978 and came into medical use in 1992. ^[3] Cinolazepam is mainly used in Romania and Slovakia; it not approved for sale in the United States or Canada.

References

1. US Patent 4388313 Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof
2. Lannacher Romania (1999). "Gerodorm". Produse Gerot inregistrate in Romania (in Romanian). Archived from the original on 11 October 2006. Retrieved 17 August 2006.
3. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 530. ISBN   9783527607495.

External links

• Inchem.org - Cinolazepam