Thienobenzodiazepine

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General structure of thienobenzodiazepines. Core is highlighted by black and color. Grey depicts accessory functional groups. It's Molecular Weight is 200.26 g/mol Examples of thienobenzodiazepines.svg
General structure of thienobenzodiazepines. Core is highlighted by black and color. Grey depicts accessory functional groups. It's Molecular Weight is 200.26 g/mol

Thienobenzodiazepine is a heterocyclic compound containing a diazepine ring fused to a thiophene ring and a benzene ring. Thienobenzodiazepine forms the central core of pharmaceutical drugs including atypical antipsychotic olanzapine (Zyprexa) and antimuscarinic telenzepine. Thienobenzodiazepines act relatively selectively at the α2 subunit of the GABAA receptor. [1]

References

  1. 1 2 Bymaster, Frank P; Calligaro, David O; Falcone, Julie F; Marsh, Richard D; Moore, Nicholas A; Tye, Nicholas C; Seeman, Philip; Wong, David T (February 1996). "Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine". Neuropsychopharmacology. 4 (2): 87–96. doi:10.1016/0893-133X(94)00129-N. PMID   8822531.


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