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| Clinical data | |
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| MedlinePlus | a682284 |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.117.754  |
| Chemical and physical data | |
| Formula | C17H20N2S |
| Molar mass | 284.42 g·mol−1 |
| 3D model (JSmol) | |
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Isopromethazine is an antihistamine and anticholinergic of the phenothiazine chemical class. It is structurally analogous to promethazine.
Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. The derivatives chlorpromazine and promethazine revolutionized the field of psychiatry and allergy treatment, respectively. An earlier derivative, methylene blue, was one of the first antimalarial drugs, and derivatives are under investigation as possible anti-infective drugs. Phenothiazine is a prototypical pharmaceutical lead structure in medicinal chemistry.
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. They may be used for severe cases of gastroenteritis, especially if the patient is dehydrated.
ATC code D04Antipruritics, including antihistamines, anesthetics, etc. is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup D04 is part of the anatomical group D Dermatologicals.
ATC code R06Antihistamines for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup R06 is part of the anatomical group R Respiratory system.
Promethazine is a first-generation antihistamine. It is used to treat allergies, trouble sleeping, and nausea. It may help with some symptoms associated with the common cold. It may also be used for sedating people who are agitated or anxious. It is available by mouth as a syrup, as a rectal suppository, or by injection into a muscle.
Chopped and screwed is a technique of remixing hip hop music which developed in the Houston hip hop scene in the early 1990s by DJ Screw. The screwed technique is accomplished by slowing the tempo down to 60 and 70 quarter-note beats per minute and applying techniques such as skipping beats, record scratching, stop-time, and affecting portions of the original composition to create a "chopped-up" version of the song.
Sominex is the trademarked name for several over the counter sleep aids.
Propiomazine is an antihistamine blocking H1 receptors. It is used to treat insomnia, and to produce sleepiness or drowsiness and to relieve anxiety before or during surgery or other procedures and in combination with analgetics also during labor. Propiomazine is a phenothiazine, but is not used as a neuroleptic because it does not block dopamine receptors well.
Tricyclics are chemical compounds that contain three interconnected rings of atoms.
Lean, also known as purple drank and several other names, is a recreational drug cocktail, prepared by combining prescription-grade cough syrup with a soft drink and hard candy. The concoction originated in Houston, Texas, and is popular among those who belong to the hip hop subculture or reside in the southern United States.
Thebacon, or dihydrocodeinone enol acetate, is a semisynthetic opioid that is similar to hydrocodone and is most commonly synthesised from thebaine. Thebacon is a derivative of acetyldihydrocodeine, where only the 6–7 double bond is saturated. Thebacon is marketed as its hydrochloride salt under the trade name Acedicon, and as its bitartrate under Diacodin and other trade names. The hydrochloride salt has a free base conversion ratio of 0.846. Other salts used in research and other settings include thebacon's phosphate, hydrobromide, citrate, hydroiodide, and sulfate. The US DEA Administrative Controlled Substance Control Number assigned by the Controlled Substances Act 1970 for thebacon and all of its salts is 9737.
Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic. It is nowadays scarcely used in the 1st line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).
A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action at serotonin (5-HT) receptors.
Hydroxyethylpromethazine is an antihistamine with anticholinergic properties. It is structurally analogous to promethazine.
Thiazinamium metilsulfate (INN) or thiazinam is an antihistamine. The USAN is thiazinamium chloride.
The drug combination prednisolone/promethazine is an antidote for snake bites.
Propizepine is a tricyclic antidepressant (TCA) used in France for the treatment of depression which was introduced in the 1970s.
Fenethazine (INN), or phenethazine, is a first-generation antihistamine of the phenothiazine group. Promethazine, and subsequently chlorpromazine, were derived from fenethazine. Fenethazine, in turn, was derived from phenbenzamine.
An analgesic adjuvant is a medication that is typically used for indications other than pain control but provides control of pain in some painful diseases. Antiemetics and medication to relieve constipation are two examples of non-adjuvant medication indications because these are used to treat side effects and adverse effects. Examples include:
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