VUF-5681

VUF-5681

Names
Preferred IUPAC name 4-[3-(1H-Imidazol-5-yl)propyl]piperidine
Identifiers
CAS Number	768358-61-8  Y
3D model (JSmol)	Interactive image
ChemSpider	8505701  N
PubChem CID	10330240
UNII	WR5V5TB2TR  Y
CompTox Dashboard (EPA)	DTXSID501277310
InChI InChI=1S/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14) N Key: YPGRNKJNOSUCLY-UHFFFAOYSA-N N InChI=1/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14) Key: YPGRNKJNOSUCLY-UHFFFAOYAZ
SMILES C1CNCCC1CCCC2=CN=CN2
Properties
Chemical formula	C11H19N3
Molar mass	193.288 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H₃ subtype. ^[1] However while VUF-5681 blocks the activity of more potent H₃ agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself. ^[2]

References

1. Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J (September 2006). "Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway". Neuropharmacology. 51 (3): 517–23. doi:10.1016/j.neuropharm.2006.04.010. PMID   16769092. S2CID   25209099.
2. Baker JG (June 2008). "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC Pharmacology. 8: 9. doi: 10.1186/1471-2210-8-9 . PMC   2430196 . PMID   18538007.