4-Methyldiphenhydramine

p-Methyldiphenhydramine

Identifiers
IUPAC name N,N-Dimethyl-2-[(4-methylphenyl)(phenyl)methoxy]ethanamine
CAS Number	19804-27-4
PubChem CID	19935
ChemSpider	18776  Y
UNII	P9633413CU
CompTox Dashboard (EPA)	DTXSID20903322
ECHA InfoCard	100.039.375
Chemical and physical data
Formula	C18H23NO
Molar mass	269.388 g·mol−1
3D model (JSmol)	Interactive image
SMILES O(CCN(C)C)C(c1ccccc1)c2ccc(cc2)C
InChI InChI=1S/C18H23NO/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3 Y Key:PJUYQWIDNIAHIZ-UHFFFAOYSA-N Y
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4-Methyldiphenhydramine is an antihistamine and anticholinergic. ^{[1] [2]}

It is structurally analogous to diphenhydramine.

References

1. Rekker RF, Timmerman H, Harms AF, Nauta WT (May 1971). "The antihistaminic and anticholinergic activities of optically active diphenhydramine derivatives. The concept of complementarity". Arzneimittel-Forschung. 21 (5): 688–91. PMID   4398311.
2. Rekker RF, Timmerman H, Nauta WT (1972). "Changes in antihistaminic and anticholinergic activities of diphenhydramine derivatives on quaternization and the role of an asymmetric centre". Chimica Therapeutica. 7 (4): 279–282.