SCH-79687

SCH-79687
Names
	Preferred IUPAC name N-(3,5-Dichlorophenyl)-N′-({4-[(1H-imidazol-4-yl)methyl]phenyl}methyl)urea
Identifiers
CAS Number	224585-45-9 ;
3D model (JSmol)	Interactive image ;
ChEMBL	ChEMBL366977 ;
ChemSpider	7977505 ;
PubChem CID	9801743 ;
UNII	YF792N2EXV ;
CompTox Dashboard (EPA)	DTXSID20430941 ;
	InChI InChI=1S/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25) Key: CXNCQFJNXQAFND-UHFFFAOYSA-N ; InChI=1/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25) Key: CXNCQFJNXQAFND-UHFFFAOYAC;
	SMILES Clc1cc(cc(Cl)c1)NC(=O)NCc2ccc(cc2)Cc3c[nH]cn3;
Properties
Chemical formula	C18H16Cl2N4O
Molar mass	375.251 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated October 16, 2025

SCH-79687 is a histamine antagonist selective for the H₃ subtype.^[1]

References

↑ McLeod, RL; Rizzo, CA; West, RE Jr; Aslanian, R; McCormick, K; Bryant, M; Hsieh, Y; Korfmacher, W; Mingo, GG; Varty, L; Williams, SM; Shih, NY; Egan, RW; Hey, JA (Jun 2003). "Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)". Journal of Pharmacology and Experimental Therapeutics. 305 (3): 1037–44. doi:10.1124/jpet.103.049254. PMID 12649305.

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[1] McLeod, RL; Rizzo, CA; West, RE Jr; Aslanian, R; McCormick, K; Bryant, M; Hsieh, Y; Korfmacher, W; Mingo, GG; Varty, L; Williams, SM; Shih, NY; Egan, RW; Hey, JA (Jun 2003). "Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)". Journal of Pharmacology and Experimental Therapeutics. 305 (3): 1037–44. doi:10.1124/jpet.103.049254. PMID 12649305.

[1]

Names

Preferred IUPAC name N-(3,5-Dichlorophenyl)-N′-({4-[(1H-imidazol-4-yl)methyl]phenyl}methyl)urea
Identifiers
CAS Number	224585-45-9 ^N
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL366977 ^Y
ChemSpider	7977505 ^Y
PubChem CID	9801743
UNII	YF792N2EXV ^Y
CompTox Dashboard (EPA)	DTXSID20430941
InChI InChI=1S/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25)^Y Key: CXNCQFJNXQAFND-UHFFFAOYSA-N^Y InChI=1/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25) Key: CXNCQFJNXQAFND-UHFFFAOYAC
SMILES Clc1cc(cc(Cl)c1)NC(=O)NCc2ccc(cc2)Cc3c[nH]cn3
Properties
Chemical formula	C₁₈H₁₆Cl₂N₄O
Molar mass	375.251 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references