Fenethazine

Fenethazine

Clinical data
Other names	Phenethazinum, Phenethazine, Phenetazine; RP-3015, SC-1627, WY-1143
Identifiers
IUPAC name N,N-Dimethyl-2-phenothiazin-10-ylethanamine
CAS Number	522-24-7  Y
PubChem CID	68223
ChemSpider	61526  Y
UNII	8J97CUZ4HX
KEGG	D02602
ChEMBL	ChEMBL2106299  Y
CompTox Dashboard (EPA)	DTXSID30200233
ECHA InfoCard	100.007.570
Chemical and physical data
Formula	C16H18N2S
Molar mass	270.39 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCN1C2=CC=CC=C2SC3=CC=CC=C31
InChI InChI=1S/C16H18N2S/c1-17(2)11-12-18-13-7-3-5-9-15(13)19-16-10-6-4-8-14(16)18/h3-10H,11-12H2,1-2H3 Y Key:PFAXACNYGZVKMX-UHFFFAOYSA-N Y

Fenethazine (INN; brand names Anergen, Contralergial, Ethysine, Etisine, Lisergan, Lysergan; former developmental codes RP-3015, SC-1627, and WY-1143; also known as phenethazine) is a first-generation antihistamine of the phenothiazine group. ^[1] Promethazine and chlorpromazine, were derived from fenethazine. ^[2] Fenethazine, in turn, was derived from phenbenzamine. ^[3]

References

1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 434–. ISBN   978-1-4757-2085-3.
2. Dörwald FZ (4 February 2013). Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. pp. 301–. ISBN   978-3-527-64565-7.
3. Sneader W (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 404–. ISBN   978-0-471-89979-2.