Last updated
Clinical data
ATC code
  • N,N-dimethyl-3-(4-methylphenyl)-3-phenylpropan-1-amine
CAS Number
PubChem CID
ECHA InfoCard 100.024.611 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C18H23N
Molar mass 253.389 g·mol−1
3D model (JSmol)
  • c1cc(ccc1C(c2ccccc2)CCN(C)C)C
  • InChI=1S/C18H23N/c1-15-9-11-17(12-10-15)18(13-14-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3 Yes check.svgY

Tolpropamine is an antihistamine and anticholinergic used as an antipruritic. [1]

Related Research Articles

Dermatology is the branch of medicine dealing with the skin. It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medical doctor who manages diseases related to skin, hair, nails, and some cosmetic problems.

<span class="mw-page-title-main">Psoriasis</span> Skin disease

Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by raised areas of abnormal skin. These areas are red, or purple on some people with darker skin, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete body coverage. Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.

Intense pulsed light (IPL) is a technology used by cosmetic and medical practitioners to perform various skin treatments for aesthetic and therapeutic purposes, including hair removal, photorejuvenation as well as to alleviate dermatologic diseases such as acne. IPL is increasingly used in optometry and ophthalmology as well, to treat evaporative dry eye disease due to meibomian gland dysfunction.

<span class="mw-page-title-main">Itch</span> Sensation that causes the desire or reflex to scratch

Itch is a sensation that causes the desire or reflex to scratch. Itch has resisted many attempts to be classified as any one type of sensory experience. Itch has many similarities to pain, and while both are unpleasant sensory experiences, their behavioral response patterns are different. Pain creates a withdrawal reflex, whereas itch leads to a scratch reflex.

ATC code D04Antipruritics, including antihistamines, anesthetics, etc. is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup D04 is part of the anatomical group D Dermatologicals.

Antipruritics, abirritants, or anti-itch drugs, are medications that inhibit the itching often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, fungal infections, insect bites and stings like those from mosquitoes, fleas, and mites, and contact dermatitis and urticaria caused by plants such as poison ivy or stinging nettle. It can also be caused by chronic kidney disease and related conditions.

<span class="mw-page-title-main">Pseudofolliculitis barbae</span> Medical condition

Pseudofolliculitis barbae (PFB) is a persistent irritation caused by shaving. It was first described in 1956.

<span class="mw-page-title-main">Dyshidrosis</span> Human disease

Dyshidrosis is a type of dermatitis that is characterized by itchy blisters on the palms of the hands and bottoms of the feet. Blisters are generally one to two millimeters in size and heal over three weeks. However, they often recur. Redness is not usually present. Repeated attacks may result in fissures and skin thickening.

<span class="mw-page-title-main">Desonide</span>

Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory that has been available since the 1970s. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile and is available as a cream, ointment, lotion, and as a foam under the tradename Verdeso Foam. Other trade names for creams, lotions, and ointments include Tridesilon, DesOwen, Desonate. It is a group VI corticosteroid under US classification, the second least potent group.

Aquagenic pruritus is a skin condition characterized by the development of severe, intense, prickling-like epidermal itching without observable skin lesions and evoked by contact with water.

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin. It has also been used to treat varicose veins, hemangiomas, and vascular malformations. It is formed by the ethoxylation of dodecanol.

<span class="mw-page-title-main">Alclometasone</span>

Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.

Anusol is a brand of medications that can be used to treat hemorrhoids. The Anusol range includes creams, ointments, and suppositories. Anusol is now known under the brand name Tucks in the United States and some other areas while being marketed under the Anusol name in other markets. The active ingredients and usage remains unchanged between these brand names.

<span class="mw-page-title-main">Sertaconazole</span>

Sertaconazole, sold under the brand name Ertaczo among others, is an antifungal medication of the Benzothiophene class. It is available as a cream to treat skin infections such as athlete's foot.

Itching powder is a powder or powder-like substance that induces itching when applied onto human skin. This is usually done as a practical joke or prank to an unsuspecting victim.

<span class="mw-page-title-main">Thenalidine</span> Chemical compound

Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia.

<span class="mw-page-title-main">Alimemazine</span> Chemical compound

Alimemazine (INN), also known as trimeprazine,, commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic. In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders, organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses.

<span class="mw-page-title-main">Nalfurafine</span> Antipruritic drug

Nalfurafine is an antipruritic that is marketed in Japan for the treatment of uremic pruritus in individuals with chronic kidney disease undergoing hemodialysis. It acts as a potent, selective, centrally-penetrant κ-opioid receptor (KOR) agonist, and is the first and currently the only selective KOR agonist to have been approved for clinical use. It has also been dubiously referred to as the "first non-narcotic opioid drug" in history.

<span class="mw-page-title-main">Notalgia paresthetica</span> Neuropathy causing itching between the shoulder blades

Notalgia paresthetica or Notalgia paraesthetica (NP) is a chronic sensory neuropathy. Notalgia paresthetica is a common localized itch, affecting mainly the area between the shoulder blades but occasionally with a more widespread distribution, involving the shoulders, back, and upper chest. The characteristic symptom is pruritus on the back, usually on the left hand side below the shoulder blade. It is occasionally accompanied by pain, paresthesia, or hyperesthesia, which results in a well circumscribed hyperpigmentation of a skin patch in the affected area.

<span class="mw-page-title-main">S-444,823</span> Chemical compound

S-444,823 is a drug developed by Shionogi which is a cannabinoid agonist. It was developed as an antipruritic, and has moderate selectivity for the CB2 subtype, having a CB2 affinity of 18nM, and 32x selectivity over the CB1 receptor. In animal studies it showed analgesic effects and strongly reduced itching responses, but without producing side effects such as sedation and catalepsy that are seen with centrally acting CB1 agonists.


  1. Kutscher B (2000-06-15). "Dermatologicals (D), 2. Antifungals (D01), Emollients and Protectives (D02), and Antipruritics (D04) for Dermatological Use". In Ley C (ed.). Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.w08_w01. ISBN   978-3-527-30385-4.